Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ica.2004.09.024
Title: Platinum(II) triammine antitumour complexes: Structure-activity relationship with guanosine 5′-monophosphate (5′-GMP)
Authors: Jin, V.X.
Tan, S.I.
Ranford, J.D. 
Keywords: HPLC
Multinuclear NMR
Platinum-triamine complex
Issue Date: 10-Feb-2005
Citation: Jin, V.X., Tan, S.I., Ranford, J.D. (2005-02-10). Platinum(II) triammine antitumour complexes: Structure-activity relationship with guanosine 5′-monophosphate (5′-GMP). Inorganica Chimica Acta 358 (3) : 677-686. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ica.2004.09.024
Abstract: The multinuclear ( 1H, 15N, 31P and 195Pt) NMR spectroscopies, ES-MS and HPLC have been employed to investigate the structure-activity relationship for the reactions between guanosine 5′-monophosphate (5′-GMP) and the platinum(II)-triamine complexes of the general formulation cis-[Pt(NH 3) 2(Am)Cl] NO 3 (where Am represents a substituted pyridine). The order of reaction rate of the reactions was found to be: 3-phpy > 4-phpy > py > 4-mepy > 3-mepy > 2-mepy. The two basic factors, steric and electronic, were attributed to the order of the binding rate constants. A possible mechanism of the reaction of cis-[Pt(NH 3) 2(Am)Cl] + with 5′-GMP suggested that the reactions proceed via direct nucleophilic attack and no loss of ammonia. cis-[Pt(NH 3) 2(Am)Cl] + binds to the N7 nitrogen of the guanine residue of 5′-GMP to form a coordinate bond with the Pt metal centre. This mechanism is apparently different from that of cisplatin. The pK a value of cis-[Pt(NH 3) 2(4-mepy)(H 2O)](NO 3) 2 (5.63) has been determined at 298 K by the use of distortionless enhancement by polarization transfer (DEPT) 15N NMR spectroscopy and compared to the pK a value of cis-[PtCl(H 2O)(NH 3) 2] +. © 2004 Elsevier B.V. All rights reserved.
Source Title: Inorganica Chimica Acta
URI: http://scholarbank.nus.edu.sg/handle/10635/94541
ISSN: 00201693
DOI: 10.1016/j.ica.2004.09.024
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

20
checked on Jul 19, 2018

WEB OF SCIENCETM
Citations

21
checked on Jun 25, 2018

Page view(s)

30
checked on Jun 22, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.