Please use this identifier to cite or link to this item: https://doi.org/10.1039/AN9941901669
Title: Orthogonal array design as a chemometric method for the optimization of analytical procedures. Part 2. Four-level design and its application in microwave dissolution of biological samples
Authors: Lan, W.G.
Wong, M.K. 
Chen, N.
Sin, Y.M. 
Issue Date: 1994
Source: Lan, W.G., Wong, M.K., Chen, N., Sin, Y.M. (1994). Orthogonal array design as a chemometric method for the optimization of analytical procedures. Part 2. Four-level design and its application in microwave dissolution of biological samples. The Analyst 119 (8) : 1669-1675. ScholarBank@NUS Repository. https://doi.org/10.1039/AN9941901669
Abstract: The theory and methodology of a four-level orthogonal array design were developed for the optimization of analytical procedures. The construction and characteristics of an OA16(45) matrix are described in detail, and the orthogonality of the matrix is shown by means of a third-order regression model. The response surface methodology for the OA 16(45) matrix was then developed by using the equations obtained from the proof of orthogonality. Microwave dissolution for the determination of selenium in biological samples by hydride generation atomic absorption spectrometry was used as a practical example to demonstrate the application of the proposed four-level orthogonal array design with response surface methodology.
Source Title: The Analyst
URI: http://scholarbank.nus.edu.sg/handle/10635/94458
ISSN: 00032654
DOI: 10.1039/AN9941901669
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