Please use this identifier to cite or link to this item:
|Title:||L-Methionine increases the rate of reaction of 5′-guanosine monophosphate with the anticancer drug cisplatin: Mixed-ligand adducts and reversible methionine binding|
Del Socorro Murdoch, P.
|Citation:||Barnham, K.J., Djuran, M.I., Del Socorro Murdoch, P., Ranford, J.D., Sadler, P.J. (1995). L-Methionine increases the rate of reaction of 5′-guanosine monophosphate with the anticancer drug cisplatin: Mixed-ligand adducts and reversible methionine binding. Journal of the Chemical Society, Dalton Transactions (22) : 3721-3726. ScholarBank@NUS Repository. https://doi.org/10.1039/DT9950003721|
|Abstract:||L-Methionine (L-HMet) increased the rate of reaction of the anticancer drug cisplatin, cis-[PtCl2(NH3)2], with guanosine 5′-monophosphate (5′-GMP) at pH 7. The course of the reaction has been elucidated by 1H and [1H, 15N] NMR spectroscopy. Novel intermediates detected and characterized include cis-[Pt(5′-GMP-N7)(L-HMet-S)(NH3)2] 2+ and [Pt(L-Met-S,N)(5′-GMP-N7)(NH3)]+ (charges on 5′-GMP ignored), the formation of which involves ammine release. Monodentate S-bound L-HMet can co-ordinate reversibly, whereas S,N-chelated L-Met is much less reactive. Thus methionine residues in peptides and proteins could play a role in the transfer of Pt onto DNA. Comparative reactions of [Pt(en)Cl2] (en = 1,2-diaminoethane) have also been investigated.|
|Source Title:||Journal of the Chemical Society, Dalton Transactions|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 13, 2018
WEB OF SCIENCETM
checked on Sep 4, 2018
checked on Sep 7, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.