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|Title:||L-Methionine increases the rate of reaction of 5′-guanosine monophosphate with the anticancer drug cisplatin: Mixed-ligand adducts and reversible methionine binding|
Del Socorro Murdoch, P.
|Citation:||Barnham, K.J., Djuran, M.I., Del Socorro Murdoch, P., Ranford, J.D., Sadler, P.J. (1995). L-Methionine increases the rate of reaction of 5′-guanosine monophosphate with the anticancer drug cisplatin: Mixed-ligand adducts and reversible methionine binding. Journal of the Chemical Society, Dalton Transactions (22) : 3721-3726. ScholarBank@NUS Repository. https://doi.org/10.1039/DT9950003721|
|Abstract:||L-Methionine (L-HMet) increased the rate of reaction of the anticancer drug cisplatin, cis-[PtCl2(NH3)2], with guanosine 5′-monophosphate (5′-GMP) at pH 7. The course of the reaction has been elucidated by 1H and [1H, 15N] NMR spectroscopy. Novel intermediates detected and characterized include cis-[Pt(5′-GMP-N7)(L-HMet-S)(NH3)2] 2+ and [Pt(L-Met-S,N)(5′-GMP-N7)(NH3)]+ (charges on 5′-GMP ignored), the formation of which involves ammine release. Monodentate S-bound L-HMet can co-ordinate reversibly, whereas S,N-chelated L-Met is much less reactive. Thus methionine residues in peptides and proteins could play a role in the transfer of Pt onto DNA. Comparative reactions of [Pt(en)Cl2] (en = 1,2-diaminoethane) have also been investigated.|
|Source Title:||Journal of the Chemical Society, Dalton Transactions|
|Appears in Collections:||Staff Publications|
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