Please use this identifier to cite or link to this item: https://doi.org/10.1021/np049844c
Title: Inhibition of the human chemokine receptor CCR5 by variecolin and variecolol and isolation of four new variecolin analogues, emericolins A-D, from Emericella aurantiobrunnea
Authors: Yoganathan, K.
Rossant, C.
Glover, R.P.
Cao, S.
Vittal, J.J. 
Ng, S.
Huang, Y.
Buss, A.D.
Butler, M.S.
Issue Date: Oct-2004
Citation: Yoganathan, K., Rossant, C., Glover, R.P., Cao, S., Vittal, J.J., Ng, S., Huang, Y., Buss, A.D., Butler, M.S. (2004-10). Inhibition of the human chemokine receptor CCR5 by variecolin and variecolol and isolation of four new variecolin analogues, emericolins A-D, from Emericella aurantiobrunnea. Journal of Natural Products 67 (10) : 1681-1684. ScholarBank@NUS Repository. https://doi.org/10.1021/np049844c
Abstract: An extract from the fungus Emericella aurantiobrunnea was found to compete with macrophage inflammatory protein (MIP)-1α for binding to human CCR5 in a scintillation proximity assay (SPA). Bioassay-guided fractionation led to the isolation of variecolin (1) and variecolol (2), which had IC50 values of 9 and 32 μM, respectively. An X-ray crystal structure of variecolin (1) was obtained for the first time. Also isolated were four new inactive analogues, emericolin A (3), B (4), C (5), and D (6), and the relative stereochemistry of these compounds was determined by NMR methods using ROESY spectra and 1H/1H coupling constants.
Source Title: Journal of Natural Products
URI: http://scholarbank.nus.edu.sg/handle/10635/94054
ISSN: 01633864
DOI: 10.1021/np049844c
Appears in Collections:Staff Publications

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