Please use this identifier to cite or link to this item:
|Title:||Inhibition of the human chemokine receptor CCR5 by variecolin and variecolol and isolation of four new variecolin analogues, emericolins A-D, from Emericella aurantiobrunnea|
|Citation:||Yoganathan, K., Rossant, C., Glover, R.P., Cao, S., Vittal, J.J., Ng, S., Huang, Y., Buss, A.D., Butler, M.S. (2004-10). Inhibition of the human chemokine receptor CCR5 by variecolin and variecolol and isolation of four new variecolin analogues, emericolins A-D, from Emericella aurantiobrunnea. Journal of Natural Products 67 (10) : 1681-1684. ScholarBank@NUS Repository. https://doi.org/10.1021/np049844c|
|Abstract:||An extract from the fungus Emericella aurantiobrunnea was found to compete with macrophage inflammatory protein (MIP)-1α for binding to human CCR5 in a scintillation proximity assay (SPA). Bioassay-guided fractionation led to the isolation of variecolin (1) and variecolol (2), which had IC50 values of 9 and 32 μM, respectively. An X-ray crystal structure of variecolin (1) was obtained for the first time. Also isolated were four new inactive analogues, emericolin A (3), B (4), C (5), and D (6), and the relative stereochemistry of these compounds was determined by NMR methods using ROESY spectra and 1H/1H coupling constants.|
|Source Title:||Journal of Natural Products|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 8, 2018
WEB OF SCIENCETM
checked on Jul 24, 2018
checked on May 4, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.