Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/93894
Title: Gold nanoparticle-enabled real-time ligation chain reaction for ultrasensitive detectionof DNA
Authors: Shen, W.
Deng, H.
Gao, Z. 
Issue Date: 12-Sep-2012
Citation: Shen, W., Deng, H., Gao, Z. (2012-09-12). Gold nanoparticle-enabled real-time ligation chain reaction for ultrasensitive detectionof DNA. Journal of the American Chemical Society 134 (36) : 14678-14681. ScholarBank@NUS Repository.
Abstract: A simple and ultrasensitive colorimetric DNA assay based on the detection of the product of a ligation chain reaction (LCR) and the use of gold nanoparticles (AuNPs) as signal generators has been developed. During LCR, the AuNPs were ligated together, resulting in a distinct color change in real time after a sufficient number of thermal cycles. The cumulative nature of the protocol produced a detection limit of 20 aM with a selectivity factor of 103. © 2012 American Chemical Society.
Source Title: Journal of the American Chemical Society
URI: http://scholarbank.nus.edu.sg/handle/10635/93894
ISSN: 00027863
Appears in Collections:Staff Publications

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