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https://scholarbank.nus.edu.sg/handle/10635/93894
| Title: | Gold nanoparticle-enabled real-time ligation chain reaction for ultrasensitive detectionof DNA | Authors: | Shen, W. Deng, H. Gao, Z. |
Issue Date: | 12-Sep-2012 | Citation: | Shen, W., Deng, H., Gao, Z. (2012-09-12). Gold nanoparticle-enabled real-time ligation chain reaction for ultrasensitive detectionof DNA. Journal of the American Chemical Society 134 (36) : 14678-14681. ScholarBank@NUS Repository. | Abstract: | A simple and ultrasensitive colorimetric DNA assay based on the detection of the product of a ligation chain reaction (LCR) and the use of gold nanoparticles (AuNPs) as signal generators has been developed. During LCR, the AuNPs were ligated together, resulting in a distinct color change in real time after a sufficient number of thermal cycles. The cumulative nature of the protocol produced a detection limit of 20 aM with a selectivity factor of 103. © 2012 American Chemical Society. | Source Title: | Journal of the American Chemical Society | URI: | http://scholarbank.nus.edu.sg/handle/10635/93894 | ISSN: | 00027863 |
| Appears in Collections: | Staff Publications |
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