Enantioselective synthesis of 2-substituted and 3-substituted piperidines through a bromoaminocyclization process

Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2cc36578b

Title:	Enantioselective synthesis of 2-substituted and 3-substituted piperidines through a bromoaminocyclization process
Authors:	Zhou, L. Tay, D.W. Chen, J. Leung, G.Y.C. Yeung, Y.-Y.
Issue Date:	14-May-2013
Citation:	Zhou, L., Tay, D.W., Chen, J., Leung, G.Y.C., Yeung, Y.-Y. (2013-05-14). Enantioselective synthesis of 2-substituted and 3-substituted piperidines through a bromoaminocyclization process. Chemical Communications 49 (39) : 4412-4414. ScholarBank@NUS Repository. https://doi.org/10.1039/c2cc36578b
Abstract:	A catalytic enantioselective bromocyclization of olefinic amides using amino-thiocarbamates as the catalysts has been developed. The resulting enantioenriched 2-substituted 3-bromopiperidines can readily be transformed to 3-substituted piperidines through a silver salt-mediated rearrangement. This process has been applied to the synthesis of a dopaminergic drug, Preclamol. © 2013 The Royal Society of Chemistry.
Source Title:	Chemical Communications
URI:	http://scholarbank.nus.edu.sg/handle/10635/93744
ISSN:	13597345
DOI:	10.1039/c2cc36578b
Appears in Collections:	Staff Publications

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