Please use this identifier to cite or link to this item: https://doi.org/10.1039/c0nr00204f
Title: Active targeting of cancer cells using folic acid-conjugated platinum nanoparticles
Authors: Teow, Y.
Valiyaveettil, S. 
Issue Date: Nov-2010
Citation: Teow, Y., Valiyaveettil, S. (2010-11). Active targeting of cancer cells using folic acid-conjugated platinum nanoparticles. Nanoscale 2 (12) : 2607-2613. ScholarBank@NUS Repository. https://doi.org/10.1039/c0nr00204f
Abstract: Interaction of nanoparticles with human cells is an interesting topic for understanding toxicity and developing potential drug candidates. Water soluble platinum nanoparticles were synthesized via reduction of hexachloroplatinic acid using sodium borohydride in the presence of capping agents. The bioactivity of folic acid and poly(vinyl pyrrolidone) capped platinum nanoparticles (Pt-nps) has been investigated using commercially available cell lines. In the cell viability experiments, PVP-capped nanoparticles were found to be less toxic (>80% viability), whereas, folic acid-capped platinum nanoparticles showed a reduced viability down to 24% after 72 h of exposure at a concentration of 100 μg ml-1 for MCF7 breast cancer cells. Such toxicity, combined with the possibility to incorporate functional organic molecules as capping agents, can be used for developing new drug candidates. © 2010 The Royal Society of Chemistry.
Source Title: Nanoscale
URI: http://scholarbank.nus.edu.sg/handle/10635/93046
ISSN: 20403364
DOI: 10.1039/c0nr00204f
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

57
checked on Sep 17, 2018

WEB OF SCIENCETM
Citations

58
checked on Sep 17, 2018

Page view(s)

36
checked on Jun 29, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.