Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.immuni.2013.12.004
Title: A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens
Authors: Arora, P.
Baena, A.
Yu, K.A.
Saini, N.K.
Kharkwal, S.S.
Goldberg, M.F.
Kunnath-Velayudhan, S.
Carreño, L.J.
Venkataswamy, M.M.
Kim, J.
Lazar-Molnar, E.
Lauvau, G.
Chang, Y.-T. 
Liu, Z.
Bittman, R.
Al-Shamkhani, A.
Cox, L.R.
Jervis, P.J.
Veerapen, N.
Besra, G.S.
Porcelli, S.A.
Issue Date: 16-Jan-2014
Citation: Arora, P., Baena, A., Yu, K.A., Saini, N.K., Kharkwal, S.S., Goldberg, M.F., Kunnath-Velayudhan, S., Carreño, L.J., Venkataswamy, M.M., Kim, J., Lazar-Molnar, E., Lauvau, G., Chang, Y.-T., Liu, Z., Bittman, R., Al-Shamkhani, A., Cox, L.R., Jervis, P.J., Veerapen, N., Besra, G.S., Porcelli, S.A. (2014-01-16). A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity 40 (1) : 105-116. ScholarBank@NUS Repository. https://doi.org/10.1016/j.immuni.2013.12.004
Abstract: Many hematopoietic cell types express CD1d and are capable of presenting glycolipid antigens to invariant natural killer Tcells (iNKT cells). However, the question of which cells are the principal presenters of glycolipid antigens invivo remains controversial, and it has been suggested that this might vary depending on the structure of a particular glycolipid antigen. Here we have shown that a single type of cell, the CD8α+ DEC-205+ dendritic cell, was mainly responsible for capturing and presenting a variety of different glycolipid antigens, including multiple forms of α-galactosylceramide that stimulate widely divergent cytokine responses. After glycolipid presentation, these dendritic cells rapidly altered their expression of various costimulatory and coinhibitory molecules in a manner that was dependent on the structure of the antigen. These findings show flexibility in the outcome of two-way communication between CD8α+ dendritic cells and iNKT cells, providing a mechanism for biasing toward either proinflammatory or anti-inflammatory responses. © 2014 The Authors.
Source Title: Immunity
URI: http://scholarbank.nus.edu.sg/handle/10635/93007
ISSN: 10747613
DOI: 10.1016/j.immuni.2013.12.004
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

58
checked on Oct 11, 2018

WEB OF SCIENCETM
Citations

50
checked on Oct 2, 2018

Page view(s)

17
checked on Mar 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.