Please use this identifier to cite or link to this item:
|Title:||Kinetic and equilibrium study of the separation of propranolol enantiomers by high performance liquid chromatography on a chiral adsorbent|
|Authors:||Duan, G. |
High performance liquid chromatography
|Citation:||Duan, G., Ching, C.B., Swarup, S. (1998-03). Kinetic and equilibrium study of the separation of propranolol enantiomers by high performance liquid chromatography on a chiral adsorbent. Chemical Engineering Journal 69 (2) : 111-117. ScholarBank@NUS Repository. https://doi.org/10.1016/S1385-8947(97)00121-6|
|Abstract:||The kinetic and equilibrium constants for the chromatographic enantioseparation of racemic propranolol, using cellulose tri(3,5-dimethyl-phenylcarbamate) as the chiral stationary phase and hexane and isopropanol as the mobile phase, were evaluated by moment analysis on the basis of equilibrium-dispersive and linear driving force models. The overall mass transfer coefficients were evaluated to be 0.56 s-1 and 1.08 s-1 for the S-(-) and R-(+) enantiomers of propranolol. Other system properties, required as input parameters for the modelling and simulation of the process under consideration, including the voidage of the column and the axial dispersion coefficient, were also determined. The parameters obtained were used to simulate the two single enantiomer band profiles at different flow rates. The simulated results were found to match the experimental results quite well. These parameters are very important for the design of preparative chromatography.|
|Source Title:||Chemical Engineering Journal|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 20, 2019
WEB OF SCIENCETM
checked on Nov 29, 2017
checked on Feb 8, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.