Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.talanta.2013.03.072
Title: Simultaneous determination of PPCPs, EDCs, and artificial sweeteners in environmental water samples using a single-step SPE coupled with HPLC-MS/MS and isotope dilution
Authors: Tran, N.H.
Hu, J. 
Ong, S.L. 
Keywords: Artificial sweeteners
Endocrine disrupting chemicals
High performance liquid chromatography-tandem mass spectrometry
Pharmaceuticals and personal care products
Simultaneous determination
Solid-phase extraction (SPE)
Issue Date: 2013
Citation: Tran, N.H., Hu, J., Ong, S.L. (2013). Simultaneous determination of PPCPs, EDCs, and artificial sweeteners in environmental water samples using a single-step SPE coupled with HPLC-MS/MS and isotope dilution. Talanta 113 : 82-92. ScholarBank@NUS Repository. https://doi.org/10.1016/j.talanta.2013.03.072
Abstract: A high-throughput method for the simultaneous determination of 24 pharmaceuticals and personal care products (PPCPs), endocrine disrupting chemicals (EDCs) and artificial sweeteners (ASs) was developed. The method was based on a single-step solid phase extraction (SPE) coupled with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and isotope dilution. In this study, a single-step SPE procedure was optimized for simultaneous extraction of all target analytes. Good recoveries (≥70%) were observed for all target analytes when extraction was performed using Chromabond® HR-X (500 mg, 6 mL) cartridges under acidic condition (pH 2). HPLC-MS/MS parameters were optimized for the simultaneous analysis of 24 PPCPs, EDCs and ASs in a single injection. Quantification was performed by using 13 isotopically labeled internal standards (ILIS), which allows correcting efficiently the loss of the analytes during SPE procedure, matrix effects during HPLC-MS/MS and fluctuation in MS/MS signal intensity due to instrument. Method quantification limit (MQL) for most of the target analytes was below 10 ng/L in all water samples. The method was successfully applied for the simultaneous determination of PPCPs, EDCs and ASs in raw wastewater, surface water and groundwater samples collected in a local catchment area in Singapore. In conclusion, the developed method provided a valuable tool for investigating the occurrence, behavior, transport, and the fate of PPCPs, EDCs and ASs in the aquatic environment. © 2013 Elsevier B.V.
Source Title: Talanta
URI: http://scholarbank.nus.edu.sg/handle/10635/91220
ISSN: 00399140
DOI: 10.1016/j.talanta.2013.03.072
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