Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.talanta.2013.03.072
Title: | Simultaneous determination of PPCPs, EDCs, and artificial sweeteners in environmental water samples using a single-step SPE coupled with HPLC-MS/MS and isotope dilution | Authors: | Tran, N.H. Hu, J. Ong, S.L. |
Keywords: | Artificial sweeteners Endocrine disrupting chemicals High performance liquid chromatography-tandem mass spectrometry Pharmaceuticals and personal care products Simultaneous determination Solid-phase extraction (SPE) |
Issue Date: | 2013 | Citation: | Tran, N.H., Hu, J., Ong, S.L. (2013). Simultaneous determination of PPCPs, EDCs, and artificial sweeteners in environmental water samples using a single-step SPE coupled with HPLC-MS/MS and isotope dilution. Talanta 113 : 82-92. ScholarBank@NUS Repository. https://doi.org/10.1016/j.talanta.2013.03.072 | Abstract: | A high-throughput method for the simultaneous determination of 24 pharmaceuticals and personal care products (PPCPs), endocrine disrupting chemicals (EDCs) and artificial sweeteners (ASs) was developed. The method was based on a single-step solid phase extraction (SPE) coupled with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) and isotope dilution. In this study, a single-step SPE procedure was optimized for simultaneous extraction of all target analytes. Good recoveries (≥70%) were observed for all target analytes when extraction was performed using Chromabond® HR-X (500 mg, 6 mL) cartridges under acidic condition (pH 2). HPLC-MS/MS parameters were optimized for the simultaneous analysis of 24 PPCPs, EDCs and ASs in a single injection. Quantification was performed by using 13 isotopically labeled internal standards (ILIS), which allows correcting efficiently the loss of the analytes during SPE procedure, matrix effects during HPLC-MS/MS and fluctuation in MS/MS signal intensity due to instrument. Method quantification limit (MQL) for most of the target analytes was below 10 ng/L in all water samples. The method was successfully applied for the simultaneous determination of PPCPs, EDCs and ASs in raw wastewater, surface water and groundwater samples collected in a local catchment area in Singapore. In conclusion, the developed method provided a valuable tool for investigating the occurrence, behavior, transport, and the fate of PPCPs, EDCs and ASs in the aquatic environment. © 2013 Elsevier B.V. | Source Title: | Talanta | URI: | http://scholarbank.nus.edu.sg/handle/10635/91220 | ISSN: | 00399140 | DOI: | 10.1016/j.talanta.2013.03.072 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.