Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bmcl.2011.06.125
Title: Synthesis and antimicrobial activity of N 1-benzyl or N 1-benzyloxy-1,6-dihydro-1,3,5-triazine-2,4-diamines
Authors: Ma, X. 
Tan, S.-T.
Khoo, C.-L.
Sim, H.-M.
Chan, L.-W. 
Chui, W.-K. 
Keywords: Antibacterial agents
Dihydro-1,3,5-triazines
Mycobacterium tuberculosis
Staphylococcus aureus
Issue Date: 15-Sep-2011
Citation: Ma, X., Tan, S.-T., Khoo, C.-L., Sim, H.-M., Chan, L.-W., Chui, W.-K. (2011-09-15). Synthesis and antimicrobial activity of N 1-benzyl or N 1-benzyloxy-1,6-dihydro-1,3,5-triazine-2,4-diamines. Bioorganic and Medicinal Chemistry Letters 21 (18) : 5428-5431. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2011.06.125
Abstract: The emergence and spread of multidrug-resistant strains of Staphylococcus aureus and Mycobacterium tuberculosis are generating a threat to public health worldwide. In the current study, a series of N 1-benzyl and N 1-benzyloxy-1,6-dihydro-1,3,5-triazine-2,4-diamine derivatives were synthesized and investigated for their antimicrobial activity against S. aureus, and Mycobacterium smegmatis which is taxonomically related to M. tuberculosis. Most of the compounds exhibited good activity against M. smegmatis as determined by comparison of diameters of the zone of inhibition of test compounds and standard antibiotics. Compound 7o showed potent antimycobacterial activity against M. smegmatis without mammalian DHFR inhibition liability. The results from this study indicate that 1-benzyl derivatives of 1,6-dihydro-1,3,5- triazine-2,4-diamines may be used as lead compounds for the discovery of antimycobacterial agents. © 2011 Elsevier Ltd. All rights reserved.
Source Title: Bioorganic and Medicinal Chemistry Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/90252
ISSN: 0960894X
DOI: 10.1016/j.bmcl.2011.06.125
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