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Title: Specific detection of integrin α vβ 3 by light-up bioprobe with aggregation-induced emission characteristics
Authors: Shi, H.
Liu, J.
Geng, J.
Tang, B.Z.
Liu, B. 
Issue Date: 13-Jun-2012
Citation: Shi, H., Liu, J., Geng, J., Tang, B.Z., Liu, B. (2012-06-13). Specific detection of integrin α vβ 3 by light-up bioprobe with aggregation-induced emission characteristics. Journal of the American Chemical Society 134 (23) : 9569-9572. ScholarBank@NUS Repository.
Abstract: Specific bioprobes with fluorescence turn-on response are highly desirable for high contrast biosensing and imaging. In this work, we developed a new generation bioprobe by integrating tetraphenylsilole, a fluorogenic unit with aggregation-induced emission (AIE) characteristic, with cyclic arginine-glycine-aspartic acid tripeptide (cRGD), a targeting ligand to integrin α vβ 3 receptor. Emission of the AIE probe is switched on upon its specific binding to integrin α vβ 3, which allows quantitative detection of integrin α vβ 3 in solution and real-time imaging of the binding process between cRGD and integrin α vβ 3 on cell membrane. The probe can be used for tracking integrin α vβ 3 and for identifying integrin α vβ 3-positive cancer cells. © 2012 American Chemical Society.
Source Title: Journal of the American Chemical Society
ISSN: 00027863
DOI: 10.1021/ja302369e
Appears in Collections:Staff Publications

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