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|Title:||Specific detection of integrin α vβ 3 by light-up bioprobe with aggregation-induced emission characteristics|
|Citation:||Shi, H., Liu, J., Geng, J., Tang, B.Z., Liu, B. (2012-06-13). Specific detection of integrin α vβ 3 by light-up bioprobe with aggregation-induced emission characteristics. Journal of the American Chemical Society 134 (23) : 9569-9572. ScholarBank@NUS Repository. https://doi.org/10.1021/ja302369e|
|Abstract:||Specific bioprobes with fluorescence turn-on response are highly desirable for high contrast biosensing and imaging. In this work, we developed a new generation bioprobe by integrating tetraphenylsilole, a fluorogenic unit with aggregation-induced emission (AIE) characteristic, with cyclic arginine-glycine-aspartic acid tripeptide (cRGD), a targeting ligand to integrin α vβ 3 receptor. Emission of the AIE probe is switched on upon its specific binding to integrin α vβ 3, which allows quantitative detection of integrin α vβ 3 in solution and real-time imaging of the binding process between cRGD and integrin α vβ 3 on cell membrane. The probe can be used for tracking integrin α vβ 3 and for identifying integrin α vβ 3-positive cancer cells. © 2012 American Chemical Society.|
|Source Title:||Journal of the American Chemical Society|
|Appears in Collections:||Staff Publications|
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