Please use this identifier to cite or link to this item:
|Title:||Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging|
|Source:||Liu, J., Li, K., Geng, J., Zhou, L., Chandrasekharan, P., Yang, C.-T., Liu, B. (2013-03-07). Single molecular hyperbranched nanoprobes for fluorescence and magnetic resonance dual modal imaging. Polymer Chemistry 4 (5) : 1517-1524. ScholarBank@NUS Repository. https://doi.org/10.1039/c2py20837g|
|Abstract:||We designed and synthesized a gadolinium(iii)-decorated hyperbranched polyglycerol with a fluorescent polyhedral oligomeric silsesquioxane core (POSS-HPG-Gd), and demonstrated its application as a single-molecular nanoprobe for fluorescence and magnetic resonance dual imaging. The nanoprobe exhibited a uniform size with a mean diameter of 6 ± 1 nm revealed by transmission electron microscopy. POSS-HPG-Gd showed absorption and emission maxima at 405 and 570 nm in water, respectively, with a quantum yield of 41 ± 1%. Fluorescence cell imaging by confocal laser scanning microscopy using MCF-7 cancer cells as a model cell line revealed that the nanoprobe had been successfully internalized into the cytoplasm with high brightness, low cytotoxicity and good photostability. Further magnetic resonance imaging study demonstrated that POSS-HPG-Gd can serve as a promising probe for fluorescence and magnetic resonance dual modal imaging. © 2013 The Royal Society of Chemistry.|
|Source Title:||Polymer Chemistry|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 7, 2018
WEB OF SCIENCETM
checked on Jan 31, 2018
checked on Feb 19, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.