Please use this identifier to cite or link to this item: https://doi.org/10.1021/cg4012982
Title: Simultaneous spherical crystallization and Co-formulation of drug(s) and excipient from microfluidic double emulsions
Authors: Leon, R.A.L.
Wan, W.Y.
Badruddoza, A.Z.M.
Hatton, T.A.
Khan, S.A. 
Issue Date: 2-Jan-2014
Citation: Leon, R.A.L., Wan, W.Y., Badruddoza, A.Z.M., Hatton, T.A., Khan, S.A. (2014-01-02). Simultaneous spherical crystallization and Co-formulation of drug(s) and excipient from microfluidic double emulsions. Crystal Growth and Design 14 (1) : 140-146. ScholarBank@NUS Repository. https://doi.org/10.1021/cg4012982
Abstract: We demonstrate the fabrication of engineered pharmaceutical formulations of drug(s) and excipient as monodisperse spherical microparticles. Specifically, we fabricate monodisperse microparticles of ∼200 μm size containing crystals of a hydrophobic model drug (ROY) embedded within a hydrophilic matrix (sucrose) (DE formulation), which in turn may also contain a hydrophilic model drug (glycine) (D2E formulation). To do this, we dispense the components of the formulation into monodisperse oil-in-water-in-oil (O 1/W/O2) double emulsions using capillary microfluidics, to subsequently enable simultaneous crystallization and co-formulation via solvent evaporation. We provide detailed morphological and polymorphic characterization of the particles obtained and highlight how (a) microfluidic methods enable formulations that are nearly impossible to achieve using conventional crystallization methods, and (b) these 'bottom-up' methods could potentially circumvent several energy intensive 'top-down' processes in traditional manufacturing, thereby offering the potential of continuous, sustainable pharmaceutical crystallization coupled with advanced formulations. © 2013 American Chemical Society.
Source Title: Crystal Growth and Design
URI: http://scholarbank.nus.edu.sg/handle/10635/90159
ISSN: 15287483
DOI: 10.1021/cg4012982
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