Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijpharm.2006.06.013
Title: Self-assembled nanoparticles of poly(lactide)-Vitamin E TPGS copolymers for oral chemotherapy
Authors: Zhang, Z. 
Feng, S.-S. 
Keywords: Biodegradable polymers
Cancer
Cancer nanotechnology
GI barrier
Nanomedicine
Oral drug delivery
Taxol®
Issue Date: 6-Nov-2006
Source: Zhang, Z., Feng, S.-S. (2006-11-06). Self-assembled nanoparticles of poly(lactide)-Vitamin E TPGS copolymers for oral chemotherapy. International Journal of Pharmaceutics 324 (2) : 191-198. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijpharm.2006.06.013
Abstract: Nanoparticles (NPs) of poly(lactide)-Vitamin E TPGS (PLA-TPGS) copolymers were synthesized by a dialysis method in the present study to formulate paclitaxel for oral chemotherapy with Caco-2 cells as an in vitro model of the gastrointestinal (GI) drug barrier. The PLA-TPGS NPs were of size 340 nm in diameter with 5.2% drug loading. The drug release kinetics showed a 31% initial burst in the first day, followed by 80% accumulative drug release after 30 days in the PBS buffer at pH 7.4, and the release rate was found lower in simulated gastric and intestinal conditions. The internalization of fluorescent PLA-TPGS NPs by Caco-2 cells was visualized by confocal laser scanning microscopy (CLSM). PLA-TPGS NPs showed significant increase in the cellular uptake by 1.8- and 1.4-fold in comparison with poly(lactide-co-glycolide) (PLGA) NPs cultured with HT-29 and Caco-2 cells, respectively, and the cellular uptake efficiency was found affected by the incubation time and the particle concentration in the culture medium. Investigation on HT-29 and Caco-2 cytotoxicity showed advantages of the PLA-TPGS NP formulation versus Taxol®. The IC50 of the PLA-TPGS NP formulation with HT-29 cells was found 40% lower than of Taxol® at the same dose of paclitaxel. The results obtained in this research demonstrated feasibility for the PLA-TPGS NPs to be applied for oral delivery of paclitaxel as well as other anticancer drugs. © 2006 Elsevier B.V. All rights reserved.
Source Title: International Journal of Pharmaceutics
URI: http://scholarbank.nus.edu.sg/handle/10635/90108
ISSN: 03785173
DOI: 10.1016/j.ijpharm.2006.06.013
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

63
checked on Mar 7, 2018

WEB OF SCIENCETM
Citations

51
checked on Mar 7, 2018

Page view(s)

32
checked on Apr 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.