Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.seppur.2008.10.050
Title: Multi-objective optimization of simulated moving bed and Varicol processes for enantio-separation of racemic pindolol
Authors: Zhang, Y.
Hidajat, K. 
Ray, A.K.
Keywords: Biochemical engineering
Chromatography
Design
Enantio-separation
Multi-objective optimization
Pareto optimal solutions
Racemate
Simulated moving bed
Varicol
Issue Date: 12-Mar-2009
Citation: Zhang, Y., Hidajat, K., Ray, A.K. (2009-03-12). Multi-objective optimization of simulated moving bed and Varicol processes for enantio-separation of racemic pindolol. Separation and Purification Technology 65 (3) : 311-321. ScholarBank@NUS Repository. https://doi.org/10.1016/j.seppur.2008.10.050
Abstract: Rigorous multi-objective optimization of simulated moving bed (SMB) and Varicol processes for enantio-separation of racemic pindolol, a nonselective beta blocker in terms of cardio-selectivity, was carried out in this study using an experimentally verified mathematical model and isotherm parameters. Several two-objective optimization problems were solved simultaneously maximizing product purity and recovery for both SMB and Varicol processes. The shift in Pareto optimal solutions was investigated to study the effect of feed concentration, eluent flow rate as well as column geometry and column configuration. A state-of-the-art optimization technique, non-dominated sorting genetic algorithm with jumping genes (NSGA-II-JG) was used to obtain the Pareto optimal solutions. Significant performance improvement was achieved when rigorous optimization was performed. Subsequently, the optimized solutions were verified experimentally. The results show that operating conditions for SMB and Varicol processes should be selected as a compromise between separation performance and robustness. © 2008 Elsevier B.V. All rights reserved.
Source Title: Separation and Purification Technology
URI: http://scholarbank.nus.edu.sg/handle/10635/89532
ISSN: 13835866
DOI: 10.1016/j.seppur.2008.10.050
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