Please use this identifier to cite or link to this item: https://doi.org/10.1021/cm102788b
Title: Multicolor conjugate polyelectrolyte/peptide complexes as self-assembled nanoparticles for receptor-targeted cellular imaging
Authors: Pu, K.-Y. 
Li, K.
Liu, B. 
Issue Date: 28-Dec-2010
Citation: Pu, K.-Y., Li, K., Liu, B. (2010-12-28). Multicolor conjugate polyelectrolyte/peptide complexes as self-assembled nanoparticles for receptor-targeted cellular imaging. Chemistry of Materials 22 (24) : 6736-6741. ScholarBank@NUS Repository. https://doi.org/10.1021/cm102788b
Abstract: An anionic conjugated polyelectrolyte (CPE, P1) with energy donor-acceptor architecture is synthesized and assembled with an Arg-Gly-Asp (RGD) terminated peptide to form fluorescent nanoparticles (FNs) with targeting capability. Complexation between oppositely charged P1 and the peptide at different molar ratio results in FNs with different size and fluorescence varying from sky-blue to orange-red because of aggregation-enhanced fluorescence resonance energy transfer (FRET). At the P1/peptide molar ratio of 8:0.9, the FNs exhibit bright orange-red fluorescence with a quantum yield of 16% and a large Stokes shift of 195 nm. In addition, these FNs also possess low cytotoxicity and good photostability. By virtue of the specific binding between RGD and integrin receptors, the P1/peptide FNs serve as an effective probe for receptor-targeted fluorescence imaging of HT29 cancer cells. This study thus provides a facile and generic strategy to prepare a new generation of multicolor polymeric FNs with native targeting capability and controllable properties for biological applications. © 2010 American Chemical Society.
Source Title: Chemistry of Materials
URI: http://scholarbank.nus.edu.sg/handle/10635/89510
ISSN: 08974756
DOI: 10.1021/cm102788b
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

44
checked on Oct 19, 2018

WEB OF SCIENCETM
Citations

46
checked on Oct 3, 2018

Page view(s)

34
checked on Sep 21, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.