Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10856-011-4397-1
Title: Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery
Authors: Shen, S.-C.
Ng, W.K.
Shi, Z. 
Chia, L.
Neoh, K.G. 
Tan, R.B.H. 
Issue Date: Oct-2011
Citation: Shen, S.-C., Ng, W.K., Shi, Z., Chia, L., Neoh, K.G., Tan, R.B.H. (2011-10). Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery. Journal of Materials Science: Materials in Medicine 22 (10) : 2283-2292. ScholarBank@NUS Repository. https://doi.org/10.1007/s10856-011-4397-1
Abstract: Poly(methyl methacrylate)-based bone cements are functionalized with mesoporous silica nanoparticles (MSN) to enable a highly efficient and sustained release of antibiotics to reduce the risk of post-operative joint infection. To overcome the limited drug release of 5% for only 1 day with the current commercial-grade bone cements, a 8 wt% MSN-formulated bone cement is able to increase the drug release efficiency by 14-fold and sustain the release for up to 80 days. The loaded MSN is suggested to build up an effective network of rod-shaped silica particles with uniformly arranged nanoporous channels, which is responsible for the effective drug diffusion and extend time-release to the external surfaces. MSN has no detrimental effect on the critical weight-bearing bending modulus and compression strength of bone cement. In vitro assay test results show a much sustained antibacterial effect and low cytotoxicity of MSN demonstrating the potential applicability of MSN-formulated bone cement. © Springer Science+Business Media, LLC 2011.
Source Title: Journal of Materials Science: Materials in Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/89385
ISSN: 09574530
DOI: 10.1007/s10856-011-4397-1
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

39
checked on May 20, 2018

WEB OF SCIENCETM
Citations

33
checked on Apr 16, 2018

Page view(s)

36
checked on May 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.