Please use this identifier to cite or link to this item: https://doi.org/10.1007/978-3-540-92841-6_370
Title: Tissue Transglutaminase as a Biological Tissue Glue
Authors: Panengad, P.P.
Zeugolis, D.I.
Raghunath, M. 
Keywords: biological tissue glue
histochemistry
skin
Transglutaminase
Issue Date: 2009
Citation: Panengad, P.P.,Zeugolis, D.I.,Raghunath, M. (2009). Tissue Transglutaminase as a Biological Tissue Glue. IFMBE Proceedings 23 : 1496-1498. ScholarBank@NUS Repository. https://doi.org/10.1007/978-3-540-92841-6_370
Abstract: Surgeons have long sought an efficient biological method of wound repair that requires little time and minimizes discomfort for their patients, yet produces a good cosmetic outcome. Our aim is to develop a biological tissue glue based on the extracellular matrix stabilizing enzyme transglutaminase 2 to covalently bond tissue layers to promote suture-less closure of surgical wounds. We used human skin tissue as a model to test our hypothesis. Human skin samples were studied for endogenous transglutaminase activity and probed for target structures for commercial enzyme using standardized histochemistry. Tissue bonding between two skin sections was monitored under phase contrast microscopy.
Source Title: IFMBE Proceedings
URI: http://scholarbank.nus.edu.sg/handle/10635/88367
ISBN: 9783540928409
ISSN: 16800737
DOI: 10.1007/978-3-540-92841-6_370
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