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|Title:||Multiphoton luminescence of gold nanorods upon excitation with wavelengths away from their absorption maxima|
|Citation:||Balla, N.K., Sheppard, C.J.R., So, P.T.C. (2011). Multiphoton luminescence of gold nanorods upon excitation with wavelengths away from their absorption maxima. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 7910 : -. ScholarBank@NUS Repository. https://doi.org/10.1117/12.876014|
|Abstract:||Gold nanoparticles are quite popular as contrast agents for optical microscopy. Their strong linear and nonlinear interaction with light, coupled with their biocompatibility and resistance to photobleaching make them suitable contrasts agents for bioimaging applications. Gold nanorods have been used for in vivo two photon microscopy in small animals [PNAS 102, 15752 (2005)]. Conventional two photon microscopy with gold nanorods involves exciting these particles with femtosecond laser at wavelengths close to their longitudinal plasmon resonance (LPR). Most of the reported works used Ti:Sapphire laser with excitation wavelengths ranging from 780 nm to 850 nm. The rational was to maximize absorption of excitation wavelengths, a fraction of which gives rise to two photon luminescence. This however causes intense heating of the nanorods and unless the excitation powers are kept low, gold nanorods tend to melt [Phys Rev Lett 95, 267405 (2005)]. Another less explored way of getting multiphoton emission from gold nanorods is to excite them at long wavelengths far away from their LPR wavelength [Jour Amer Chem Soc 131, 14186 (2009)]. We are interested in femtosecond lasers operating around 1200 nm wavelengths because of their lower scattering and absorption by tissue and water. Here we compare multiphoton photon luminescence properties of gold nanorods when excited at wavelengths around 800 nm and 1200 nm. Excitation with wavelengths around 1200 nm has certain advantages like lower heating of the particles and hence prolonged durations of imaging. Other advantage is the ability to collect emission in the near infrared regions (NIR) up to 800 nm which is not possible when using excitation wavelengths around 800 nm. These features are good for deep tissue imaging. One disadvantage of this approach is lower luminescence intensity. © 2011 SPIE.|
|Source Title:||Progress in Biomedical Optics and Imaging - Proceedings of SPIE|
|Appears in Collections:||Staff Publications|
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