Please use this identifier to cite or link to this item: https://doi.org/10.1021/ma100894p
Title: Thermo-and pH-responsive association behavior of dual hydrophilic graft chitosan terpolymer synthesized via ATRP and click chemistry
Authors: Bao, H.
Li, L.
Gan, L.H.
Ping, Y.
Li, J. 
Ravi, P.
Issue Date: 13-Jul-2010
Citation: Bao, H., Li, L., Gan, L.H., Ping, Y., Li, J., Ravi, P. (2010-07-13). Thermo-and pH-responsive association behavior of dual hydrophilic graft chitosan terpolymer synthesized via ATRP and click chemistry. Macromolecules 43 (13) : 5679-5687. ScholarBank@NUS Repository. https://doi.org/10.1021/ma100894p
Abstract: A comb-like dual hydrophilic graft chitosan terpolymer, chitosan grafted with both poly[(2-dimethylamino)ethyl methacrylate] and poly(N- isopropylacrylamide) or, simply, CS(-g-PDMAEMA)-g-PNI-PAM, was synthesized by means of atom transfer radical polymerization (ATRP) and click chemistry. At first, PDMAEMA and PNIPAM were synthesized via ATRP, followed by substituting the halide end groups with azido groups. After converting CS into alkynyl-CS via amidation, PDMAEMA-N3 and PNIPAM-N3 side chains were successfully grafted onto the CS backbone via click reaction, leading to the well-defined graft terpolymer. Thermoand pH-responsive micellization behavior of the graft terpolymer in aqueous solutions was investigated by proton nuclear magnetic resonance (1H NMR), laser light scattering (LLS), surface tensiometry, zeta potential, and transmission electron microscopy (TEM). The core-shell structured micelles with PNIAPM as a core and CS/PDMAEMA as a shell were formed in acidic environment (pH < 4) at elevated temperature (>38 °C), whereas the unimers turned into the micelles with CS/PDMAEMA cores in alkaline solutions (pH > 7) at room temperature. © 2010 American Chemical Society.
Source Title: Macromolecules
URI: http://scholarbank.nus.edu.sg/handle/10635/88172
ISSN: 00249297
DOI: 10.1021/ma100894p
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