Please use this identifier to cite or link to this item: https://doi.org/10.3109/2000656X.2013.789037
Title: The effect of fibrin glue on tendon healing and adhesion formation in a rabbit model of flexor tendon injury and repair
Authors: He, M.
Gan, A.W.T.
Lim, A.Y.T.
Goh, J.C.H. 
Hui, J.H.P.
Lee, E.H.
Chong, A.K.S.
Keywords: Adhesion formation
Fibrin glue
Tendon repair
TISSEEL
Issue Date: Dec-2013
Citation: He, M., Gan, A.W.T., Lim, A.Y.T., Goh, J.C.H., Hui, J.H.P., Lee, E.H., Chong, A.K.S. (2013-12). The effect of fibrin glue on tendon healing and adhesion formation in a rabbit model of flexor tendon injury and repair. Journal of Plastic Surgery and Hand Surgery 47 (6) : 509-512. ScholarBank@NUS Repository. https://doi.org/10.3109/2000656X.2013.789037
Abstract: Fibrin glue has been widely used in a variety of surgical procedures to promote haemostasis and tissue bonding. It can also be used as a cell carrier for stem cells on tendons. However, the data about the effect of fibrin glue on flexor tendon healing is very limited. The present study examined the role of fibrin glue TISSEEL® in a rabbit model of flexor tendon injury. The rabbits were killed 3 or 8 weeks after the operation. The range-of-motion of the fingers and biomechanical properties of tendons were measured and compared between the control group and TISSEEL-treated group. The findings have shown that the range-of-motion in the TISSEEL-treated group was significantly different from that of the control group at 3 weeks after the operation. However, there is no significant difference in range-of-motion at 8 weeks after the operation. Moreover, there is no significant difference in biomechanical properties between the control group and TISSEEL-treated group. The results indicate that TISSEEL may attenuate adhesion formation at the early stage of flexor tendon repair. However, there is no significant effect on biomechanical features during tendon repair. In conclusion, this study has shown that it may be safe to use TISSEEL in tissue engineering applications for tendon regeneration and healing. © 2013 Informa Healthcare.
Source Title: Journal of Plastic Surgery and Hand Surgery
URI: http://scholarbank.nus.edu.sg/handle/10635/88161
ISSN: 2000656X
DOI: 10.3109/2000656X.2013.789037
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

9
checked on Dec 7, 2018

WEB OF SCIENCETM
Citations

8
checked on Nov 28, 2018

Page view(s)

53
checked on Dec 7, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.