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|Title:||Synthesis, functionalization, and bioconjugation of monodisperse, silica-coated gold nanoparticles: Robust bioprobes|
|Citation:||Liu, S., Han, M. (2005-06). Synthesis, functionalization, and bioconjugation of monodisperse, silica-coated gold nanoparticles: Robust bioprobes. Advanced Functional Materials 15 (6) : 961-967. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.200400427|
|Abstract:||Herein, we report an efficient process for preparing monodisperse Au@SiO2 nanoparticles using homogeneous shaking and without the use of surface-coupling silane agents or large stabilizers. The resulting pure-silica surface of the Au@SiO2 nanoparticles is very important for straightforward surface functionalization with different functional groups via well-established silica surface chemistry. Subsequent covalent bioconjugation of the aldehyde-functionalized Au@SiO2 nanoparticles with various biomolecules is successfully employed to make robust nanoprobes for fast, colorimetric DNA and protein detection based on the sequence-specific hybridization properties of DNA and the specific binding affinity between proteins, respectively. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Advanced Functional Materials|
|Appears in Collections:||Staff Publications|
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