Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.200400427
Title: Synthesis, functionalization, and bioconjugation of monodisperse, silica-coated gold nanoparticles: Robust bioprobes
Authors: Liu, S.
Han, M. 
Issue Date: Jun-2005
Citation: Liu, S., Han, M. (2005-06). Synthesis, functionalization, and bioconjugation of monodisperse, silica-coated gold nanoparticles: Robust bioprobes. Advanced Functional Materials 15 (6) : 961-967. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.200400427
Abstract: Herein, we report an efficient process for preparing monodisperse Au@SiO2 nanoparticles using homogeneous shaking and without the use of surface-coupling silane agents or large stabilizers. The resulting pure-silica surface of the Au@SiO2 nanoparticles is very important for straightforward surface functionalization with different functional groups via well-established silica surface chemistry. Subsequent covalent bioconjugation of the aldehyde-functionalized Au@SiO2 nanoparticles with various biomolecules is successfully employed to make robust nanoprobes for fast, colorimetric DNA and protein detection based on the sequence-specific hybridization properties of DNA and the specific binding affinity between proteins, respectively. © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Advanced Functional Materials
URI: http://scholarbank.nus.edu.sg/handle/10635/88154
ISSN: 1616301X
DOI: 10.1002/adfm.200400427
Appears in Collections:Staff Publications

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