Please use this identifier to cite or link to this item:
|Title:||Post-self-assembly experimentation on extruded collagen fibres for tissue engineering applications|
|Authors:||Zeugolis, D.I. |
|Keywords:||Extruded collagen fibres|
|Citation:||Zeugolis, D.I., Paul, R.G., Attenburrow, G. (2008-11). Post-self-assembly experimentation on extruded collagen fibres for tissue engineering applications. Acta Biomaterialia 4 (6) : 1646-1656. ScholarBank@NUS Repository. https://doi.org/10.1016/j.actbio.2008.05.015|
|Abstract:||Extruded collagen fibres have been shown to constitute a biomimetic three-dimensional scaffold with numerous tissue engineering applications. The multi-step fabrication process of this material provides opportunities for further advancements to improve the properties of the final product. Herein we investigated the influence of the post-self-assembly washing baths on the structural, mechanical and thermal properties of these fibres. The surface morphology and the inter-fibre packing were similar for every treatment. The overnight incubation in isopropanol yielded fibres with the highest temperature and energy of denaturation (p < 0.013). Typical s- and j-shape stress-strain curves were obtained for all treatments in the dry and wet state respectively. Rehydration of the fibres resulted in increased fibre diameter (p < 0.006) and reduced stress (p < 0.001), force (p < 0.001) and modulus (p < 0.002) values for every treatment. In the dry state, the alcohol-treated fibres were characterized by the highest stress (p < 0.002) values; whilst in the wet state the Tris-HCl-treated fibres were the weakest (p < 0.006). For every treatment, in both dry and wet state, a strong and inverse relationship between the fibre diameter and the stress at break was observed. Overall, the fibres produced were characterized by properties similar to those of native tissues. © 2008 Acta Materialia Inc.|
|Source Title:||Acta Biomaterialia|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 17, 2019
WEB OF SCIENCETM
checked on Jan 1, 2019
checked on Dec 7, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.