Please use this identifier to cite or link to this item: https://doi.org/10.1039/b900198k
Title: New thermogelling copolymers composed of heptakis(2,6-di-O-methyl)-β- cyclodextrin, poly(propylene glycol), and poly(ethylene glycol)
Authors: Yang, C. 
Ni, X.
Li, J. 
Issue Date: 2009
Citation: Yang, C., Ni, X., Li, J. (2009). New thermogelling copolymers composed of heptakis(2,6-di-O-methyl)-β- cyclodextrin, poly(propylene glycol), and poly(ethylene glycol). Journal of Materials Chemistry 19 (22) : 3755-3763. ScholarBank@NUS Repository. https://doi.org/10.1039/b900198k
Abstract: A series of new thermosensitive polyurethane copolymers composed of heptakis(2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD), poly(propylene glycol) (PPG), and poly(ethylene glycol) (PEG) blocks using 1,6-hexamethylene diisocyanate (HMDI) as a coupling agent were synthesized. Their chemical structures and molecular characteristics were studied using GPC analysis and 1H NMR and 13C NMR spectral analysis. We found that the copolymers had high molecular weight and the DM-β-CD, PPG, and PEG blocks were bonded by a hexamethylene dicarbamyl (HMDC) junction. DSC analysis showed that the molar motion of the PPG and PEG segments was restricted in the copolymers. Moreover, the copolymers are amphiphilic and they have very low critical micelle concentration (CMC) values ranging from 2.63-8.51 g L -1. Upon increasing temperature, the aqueous solutions of the copolymers were found to undergo a reversible clear sol-gel-turbid sol transition. The results from phase diagrams showed that the copolymers had very low critical gelation concentration (CGC) values ranging within 3-6 wt%. The copolymers synthesized in the study are easily soluble in water at room temperature, thus hydrophobic pharmaceutical agents could be entrapped into the hydrophobic cavity of CDs or loaded in the core of micelles. Then, these pharmaceutical agents are encapsulated into the gel when the copolymer forms a gel depot at around body temperature. Hence, these copolymers have potential to be used as injectable drug delivery systems. © 2009 The Royal Society of Chemistry.
Source Title: Journal of Materials Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/87985
ISSN: 09599428
DOI: 10.1039/b900198k
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

9
checked on Oct 17, 2018

WEB OF SCIENCETM
Citations

9
checked on Oct 1, 2018

Page view(s)

35
checked on Oct 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.