Please use this identifier to cite or link to this item: https://doi.org/10.1021/ac0482864
Title: Gram-scale synthesis and biofunctionalization of silica-coated silver nanoparticles for fast colorimetric DNA detection
Authors: Liu, S.
Zhang, Z.
Han, M. 
Issue Date: 15-Apr-2005
Citation: Liu, S., Zhang, Z., Han, M. (2005-04-15). Gram-scale synthesis and biofunctionalization of silica-coated silver nanoparticles for fast colorimetric DNA detection. Analytical Chemistry 77 (8) : 2595-2600. ScholarBank@NUS Repository. https://doi.org/10.1021/ac0482864
Abstract: A direct silica-coating method has been developed for the gram-scale synthesis of well-dispersed Ag@SiO2 nanoparticles. Subsequent surface functionalization via the well-established silica surface chemistry provided arching points for straightforward bioconjugation with amino-terminated oligonucleotides. Fast hybridization kinetics of the resulting robust oligo-modified Ag@SiO2 nanoprobes with complementary target oligonucleotides render themselves very useful for the fast colorimetric DNA detection based on the sequence-specific hybridization properties of DNA. Additionally, the reliable protocols developed in this study for preparing and functionalizing Ag@SiO2 nanoparticles can be readily extended to other silica-coated nanoparticles, which can also provide a specific platform for the covalent attachment of biomolecules such as amino-rich proteins, enzymes, or amino-terminated oligonucleotides for diverse bioapplications. © 2005 American Chemical Society.
Source Title: Analytical Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/87806
ISSN: 00032700
DOI: 10.1021/ac0482864
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