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|Title:||Enhanced control of in vivo bone formation with surface functionalized alginate microbeads incorporating heparin and human bone morphogenetic protein-2|
|Citation:||Abbah, S.A., Liu, J., Goh, J.C.H., Wong, H.-K. (2013-02-01). Enhanced control of in vivo bone formation with surface functionalized alginate microbeads incorporating heparin and human bone morphogenetic protein-2. Tissue Engineering - Part A 19 (3-4) : 350-359. ScholarBank@NUS Repository. https://doi.org/10.1089/ten.tea.2012.0274|
|Abstract:||In this study, we tested the hypothesis that a surface functionalization delivery platform incorporating heparin onto strontium alginate microbeads surfaces would convert this "naive carriers" into "mini- reservoirs" for localized in vivo delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2) that will induce functional bone regeneration. In vitro evaluation confirmed that (1) heparin incorporation could immobilize and prolong rhBMP-2 release for approximately 3 weeks; (2) a significant decrease (p|
|Source Title:||Tissue Engineering - Part A|
|Appears in Collections:||Staff Publications|
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