Please use this identifier to cite or link to this item: https://doi.org/10.1089/ten.tea.2012.0274
Title: Enhanced control of in vivo bone formation with surface functionalized alginate microbeads incorporating heparin and human bone morphogenetic protein-2
Authors: Abbah, S.A.
Liu, J.
Goh, J.C.H. 
Wong, H.-K.
Issue Date: 1-Feb-2013
Citation: Abbah, S.A., Liu, J., Goh, J.C.H., Wong, H.-K. (2013-02-01). Enhanced control of in vivo bone formation with surface functionalized alginate microbeads incorporating heparin and human bone morphogenetic protein-2. Tissue Engineering - Part A 19 (3-4) : 350-359. ScholarBank@NUS Repository. https://doi.org/10.1089/ten.tea.2012.0274
Abstract: In this study, we tested the hypothesis that a surface functionalization delivery platform incorporating heparin onto strontium alginate microbeads surfaces would convert this "naive carriers" into "mini- reservoirs" for localized in vivo delivery of recombinant human bone morphogenetic protein-2 (rhBMP-2) that will induce functional bone regeneration. In vitro evaluation confirmed that (1) heparin incorporation could immobilize and prolong rhBMP-2 release for approximately 3 weeks; (2) a significant decrease (p
Source Title: Tissue Engineering - Part A
URI: http://scholarbank.nus.edu.sg/handle/10635/87766
ISSN: 19373341
DOI: 10.1089/ten.tea.2012.0274
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