Please use this identifier to cite or link to this item:
|Title:||Elucidating rheological property enhancements in supramolecular hydrogels of short poly[(R,S)-3-hydroxybutyrate]-based amphiphilic triblock copolymer and α-cyclodextrin for injectable hydrogel applications|
|Citation:||Liu, K.L., Zhu, J.-L., Li, J. (2010). Elucidating rheological property enhancements in supramolecular hydrogels of short poly[(R,S)-3-hydroxybutyrate]-based amphiphilic triblock copolymer and α-cyclodextrin for injectable hydrogel applications. Soft Matter 6 (10) : 2300-2311. ScholarBank@NUS Repository. https://doi.org/10.1039/b923472a|
|Abstract:||Injectable hydrogels are an increasingly important materials in biomedical applications for drug delivery as well as injectable scaffolds. Although injectable supramolecular hydrogels based on the host-guest interaction of α-cyclodextrin (α-CD) and hydrophilic polymers have been reported, systematic studies on their dynamic rheology properties in relation to the supramolecular architecture of the hydrogel are limited. We recently found that low molecular weight (Mn < 5000) poly[(R,S)-3-hydroxybutyrate]- poly(ethylene glycol)-poly[(R,S)-3-hydroxybutyrate] (PHB-PEG-PHB) triblock copolymers formed unexpectedly strong hydrogels with α-CD. Herein, we elucidate the unexpected rheological behavior of the supramolecular hydrogel using dynamic rheology and X-ray diffraction measurements, in comparison with model systems that use low or high molecular weight PEGs as alternative guest polymers. Based on fluorescence probe spectroscopy, dynamic light scattering measurements and transmission electron microscopy, the self-assembly property of PHB-PEG-PHB was confirmed, and it is this hydrophobically associative nature of PHB-PEG-PHB that confers a high G′ value in the order of 10 4-105 Pa to the supramolecular hydrogels, along with high yield stress value of over 102 Pa and fast structural recovery after yielding. Hence, this study highlighted the usefulness of the hydrophobic interaction of a guest polymer, in addition to polymer molecular weight, polymer/α-CD ratio and overall solid content, to modulate the hydrogel stiffness, strength, and a very important parameter for injectable hydrogels: structural recovery rate. © 2010 The Royal Society of Chemistry.|
|Source Title:||Soft Matter|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 21, 2018
WEB OF SCIENCETM
checked on Jun 11, 2018
checked on May 11, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.