Please use this identifier to cite or link to this item: https://doi.org/10.1002/marc.201300598
Title: Tailoring the LCST of PNIPAAM-b-PLA-b-PNIPAAM triblock copolymers via stereocomplexation
Authors: Zhang, X.
Tan, B.H.
He, C. 
Keywords: block-copolymer
LCST, PLA, PNIPAAM
stereocomplex
Issue Date: Nov-2013
Citation: Zhang, X., Tan, B.H., He, C. (2013-11). Tailoring the LCST of PNIPAAM-b-PLA-b-PNIPAAM triblock copolymers via stereocomplexation. Macromolecular Rapid Communications 34 (22) : 1761-1766. ScholarBank@NUS Repository. https://doi.org/10.1002/marc.201300598
Abstract: Poly(N-isopropylacrylamide)-block-poly(l-lactic acid)-block-poly(N- isopropylacrylamide) (PNIPAAM-b-PLLA-b-PNIPAAM) and PNIPAAM-b-PDLA-b-PNIPAAM triblock copolymers with varying polylactic acid (PLA) lengths are synthesized using a combination of ring-opening polymerization and atom-transfer radical polymerization. Results of 1H NMR and gel permeation chromatography analyses show that the copolymers have a well-defined triblock structure and the PLA segment lengths can be readily controlled with monomer feed ratio. Stereocomplexation between the enantiomeric PLA segments is confirmed with differential scanning calorimetry and wide-angle X-ray scattering. Dynamic light scattering experiments show that (1) the LCST of PNIPAAM in water could be tailored from 32 °C up to 38.5°C by increasing the length of PLA segments and mixing copolymers of similar molecular weight with enantiomeric PLA segments to induce stereocomplexation, and (2) the LCST of each mixed copolymer system could be tailored within a 2-3°C range of body temperature by manipulating the ratio of the enantiomeric copolymers in solution. PNIPAAM-b-PLA-b-PNIPAAM triblock copolymers with varying PLA Lengths are synthesized. Stereocomplexation between enantiomeric PLA chains enables copolymers with PLA DP > 80 to reach LCST above the body temperature. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Macromolecular Rapid Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/86775
ISSN: 10221336
DOI: 10.1002/marc.201300598
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