Silica-F127 nanohybrid-encapsulated manganese oxide nanoparticles for optimized T1 magnetic resonance relaxivity

Please use this identifier to cite or link to this item: https://doi.org/10.1039/c3nr04378a

Title:	Silica-F127 nanohybrid-encapsulated manganese oxide nanoparticles for optimized T1 magnetic resonance relaxivity
Authors:	Wei Hsu, B.Y. Wang, M. Zhang, Y. Vijayaragavan, V. Wong, S.Y. Yuang-Chi Chang, A. Bhakoo, K.K. Li, X. Wang, J.
Issue Date:	7-Jan-2014
Citation:	Wei Hsu, B.Y., Wang, M., Zhang, Y., Vijayaragavan, V., Wong, S.Y., Yuang-Chi Chang, A., Bhakoo, K.K., Li, X., Wang, J. (2014-01-07). Silica-F127 nanohybrid-encapsulated manganese oxide nanoparticles for optimized T1 magnetic resonance relaxivity. Nanoscale 6 (1) : 293-299. ScholarBank@NUS Repository. https://doi.org/10.1039/c3nr04378a
Abstract:	To properly engineer MnO nanoparticles (MONPs) of high r1 relaxivity, a nanohybrid coating consisting of silica and F127 (PEO 106PPO70PEO106) is designed to encapsulate MONPs. Achieved by an interfacial templating scheme, the nanohybrid encapsulating layer is highly permeable and hydrophilic to allow for an optimal access of water molecules to the encapsulated manganese oxide core. Hence, the efficacy of MONPs as MRI contrast agents is significantly improved, as demonstrated by an enhancement of the MR signal measured with a pre-clinical 7.0 T MRI scanner. The nanohybrid encapsulation strategy also confers high colloidal stability to the hydrophobic MONPs by the surface decoration of PEO chains and a small overall diameter (
Source Title:	Nanoscale
URI:	http://scholarbank.nus.edu.sg/handle/10635/86704
ISSN:	20403364
DOI:	10.1039/c3nr04378a
Appears in Collections:	Staff Publications

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