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|Title:||Silica-F127 nanohybrid-encapsulated manganese oxide nanoparticles for optimized T1 magnetic resonance relaxivity|
|Authors:||Wei Hsu, B.Y.|
Yuang-Chi Chang, A.
|Source:||Wei Hsu, B.Y., Wang, M., Zhang, Y., Vijayaragavan, V., Wong, S.Y., Yuang-Chi Chang, A., Bhakoo, K.K., Li, X., Wang, J. (2014-01-07). Silica-F127 nanohybrid-encapsulated manganese oxide nanoparticles for optimized T1 magnetic resonance relaxivity. Nanoscale 6 (1) : 293-299. ScholarBank@NUS Repository. https://doi.org/10.1039/c3nr04378a|
|Abstract:||To properly engineer MnO nanoparticles (MONPs) of high r1 relaxivity, a nanohybrid coating consisting of silica and F127 (PEO 106PPO70PEO106) is designed to encapsulate MONPs. Achieved by an interfacial templating scheme, the nanohybrid encapsulating layer is highly permeable and hydrophilic to allow for an optimal access of water molecules to the encapsulated manganese oxide core. Hence, the efficacy of MONPs as MRI contrast agents is significantly improved, as demonstrated by an enhancement of the MR signal measured with a pre-clinical 7.0 T MRI scanner. The nanohybrid encapsulation strategy also confers high colloidal stability to the hydrophobic MONPs by the surface decoration of PEO chains and a small overall diameter (|
|Appears in Collections:||Staff Publications|
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