Please use this identifier to cite or link to this item: https://doi.org/10.1039/c3nr00774j
Title: Multifunctional PEGylated nanoclusters for biomedical applications
Authors: Peng, E.
Choo, E.S.G.
Tan, C.S.H.
Tang, X. 
Sheng, Y.
Xue, J. 
Issue Date: 5-Jul-2013
Citation: Peng, E., Choo, E.S.G., Tan, C.S.H., Tang, X., Sheng, Y., Xue, J. (2013-07-05). Multifunctional PEGylated nanoclusters for biomedical applications. Nanoscale 5 (13) : 5994-6005. ScholarBank@NUS Repository. https://doi.org/10.1039/c3nr00774j
Abstract: A simple and versatile synthesis method to form water soluble multifunctional nanoclusters using polyethylene glycol (PEG) functionalized poly(maleic anhydride-alt-1-octadecene) amphiphilic brush copolymers (PMAO-g-PEG) was presented. Simply by tuning the core size and the initial nanocrystal concentration, manganese ferrite nanoparticles (MFNPs) were used to demonstrate the versatility of tuning the loading amount of the nanoclusters. The resultant nanoclusters were found to have a well-controlled spherical shape. When Zn-doped AgInS2 quantum dots (AIZS QDs) were loaded together with the MFNP nanocrystals, bi-functional nanoclusters with fluorescent and magnetic behaviors were obtained. Such bi-functional nanoclusters were also successfully demonstrated for cellular bio-imaging. Moreover, the presence of another type of nanocrystals together with MFNPs was found to have a negligible effect on the overall properties of the nanoclusters as demonstrated by the MR relaxivity test. From the time-dependent colloidal stability test, it was found that the presence of the PEG chain grafted onto PMAO was able to reduce protein adsorption onto the nanocluster surface. An in vitro study on NIH/3T3 demonstrated the biocompatibility of the nanoclusters. Such biocompatible and colloidally stable nanoclusters with an approximate size of 80-120 nm were suitable for both MRI and cell labeling applications. © 2013 The Royal Society of Chemistry.
Source Title: Nanoscale
URI: http://scholarbank.nus.edu.sg/handle/10635/86580
ISSN: 20403364
DOI: 10.1039/c3nr00774j
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

23
checked on Jul 13, 2018

WEB OF SCIENCETM
Citations

22
checked on Jun 18, 2018

Page view(s)

26
checked on Jun 29, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.