Please use this identifier to cite or link to this item: https://doi.org/10.1088/0957-4484/17/15/045
Title: Mechanical properties of single electrospun drug-encapsulated nanofibres
Authors: Chew, S.Y.
Hufnagel, T.C.
Lim, C.T. 
Leong, K.W.
Issue Date: 14-Aug-2006
Citation: Chew, S.Y., Hufnagel, T.C., Lim, C.T., Leong, K.W. (2006-08-14). Mechanical properties of single electrospun drug-encapsulated nanofibres. Nanotechnology 17 (15) : 3880-3891. ScholarBank@NUS Repository. https://doi.org/10.1088/0957-4484/17/15/045
Abstract: The mechanical and structural properties of a surface play an important role in determining the morphology of attached cells, and ultimately their cellular functions. As such, mechanical and structural integrity are important design parameters for a tissue scaffold. Electrospun fibrous meshes are widely used in tissue engineering. When in contact with electrospun scaffolds, cells see the individual micro-or nanofibres as their immediate microenvironment. In this study, tensile testing of single electrospun nanofibres composed of poly(ε-caprolactone) (PCL), and its copolymer, poly(caprolactone-co-ethyl ethylene phosphate) (PCLEEP), revealed a size effect in the Young's modulus, E, and tensile strength, σT. Both strength and stiffness increase as the fibre diameter decreases from bulk (∼5νm) into the nanometre region (200-300nm). In particular, E and σT of individual PCL nanofibres were at least two-fold and an order of magnitude higher than that of PCL film, respectively. PCL films were observed to have more pronounced crystallographic texture than the nanofibres; however no difference in crystalline fraction, perfection, or texture was detected among the various fibres. When drugs were encapsulated into single PCLEEP fibres, mechanical properties were enhanced with 1-20wt% of loaded retinoic acid, but weakened by 10-20wt% of encapsulated bovine serum albumin. This understanding of the effect of size and drug and protein encapsulation on the mechanical properties of electrospun fibres may help in the optimization of tissue scaffold design that combines biochemical and biomechanical cues for tissue regeneration. © IOP Publishing Ltd.
Source Title: Nanotechnology
URI: http://scholarbank.nus.edu.sg/handle/10635/85389
ISSN: 09574484
DOI: 10.1088/0957-4484/17/15/045
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

109
checked on Oct 17, 2018

WEB OF SCIENCETM
Citations

99
checked on Oct 10, 2018

Page view(s)

23
checked on Oct 12, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.