Please use this identifier to cite or link to this item: https://doi.org/10.1163/156856211X617399
Title: Electrospun poly(L-lactic acid)-co-poly(ε-caprolactone) nanofibres containing silver nanoparticles for skin-tissue engineering
Authors: Jin, G.
Prabhakaran, M.P. 
Nadappuram, B.P.
Singh, G.
Kai, D.
Ramakrishna, S. 
Keywords: Antibacterial
Electrospinning
Human dermal fibroblasts
Silver nanoparticles
Wound healing
Issue Date: 2012
Citation: Jin, G., Prabhakaran, M.P., Nadappuram, B.P., Singh, G., Kai, D., Ramakrishna, S. (2012). Electrospun poly(L-lactic acid)-co-poly(ε-caprolactone) nanofibres containing silver nanoparticles for skin-tissue engineering. Journal of Biomaterials Science, Polymer Edition 23 (18) : 2337-2352. ScholarBank@NUS Repository. https://doi.org/10.1163/156856211X617399
Abstract: Silver nanoparticles (AgNPs) and silver ions (Ag+) show growth-inhibitory activity against microorganisms and have been used for decades as antibacterial agents in various fields. To fabricate a nanofibrous scaffold which is antibacterial against bacteria and non-toxic to cells, we electrospun composite poly(L-lactic acid)-co-poly(ε-caprolactone) nanofibres containing silver nanoparticles (PLLCL-AgNPs) with different concentrations (0.25, 0.50 and 0.75 wt%) of silver nitrate (AgNO3) in PLLCL. The diameters of the electro-spun PLLCL-AgNPs nanofibres decreased with the increase of AgNO 3 concentration in PLLCL solutions. Human skin fibroblasts cultured on the scaffolds showed that the PLLCL nanofibres containing lesser amounts of AgNPs (0.25 wt%) had better cell proliferation and retained the cell morphology similar to the phenotype observed on tissue culture plates (control). The antibacterial activity of AgNPs in PLLCL nanofibres was investigated against Staphylococcus aureus and Salmonella enterica and the antimicrobial activity was found to increase with the increasing concentration of nanoparticles present in the scaffold. Based on our studies, we propose that PLLCL nanofibres containing 0.25 wt% AgNO3 or PLLCL-Ag(25), favors cell proliferation and inhibits bacteria and could be a suitable substrate for wound healing. © 2012 Koninklijke Brill NV, Leiden.
Source Title: Journal of Biomaterials Science, Polymer Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/85119
ISSN: 09205063
DOI: 10.1163/156856211X617399
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