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|Title:||Effects of scaffold architecture on cranial bone healing|
|Keywords:||bone tissue engineering|
rat skull defect
|Citation:||Berner, A., Woodruff, M.A., Lam, C.X.F., Arafat, M.T., Saifzadeh, S., Steck, R., Ren, J., Nerlich, M., Ekaputra, A.K., Gibson, I., Hutmacher, D.W. (2014-04). Effects of scaffold architecture on cranial bone healing. International Journal of Oral and Maxillofacial Surgery 43 (4) : 506-513. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijom.2013.05.008|
|Abstract:||In the present study, polycaprolactone-tricalcium phosphate (PCL/TCP) scaffolds with two different fibre laydown patterns, which were coated with hydroxyapatite and gelatine, were used as an approach for optimizing bone regeneration in a critical-sized calvarial defect. After 12 weeks, bone regeneration was quantified using microcomputed tomography (micro-CT) analysis, biomechanical testing, and histological evaluation. Notably, the experimental groups with coated scaffolds showed lower bone formation and lower biomechanical properties within the defect compared to the uncoated scaffolds. Surprisingly, the different laydown pattern of the fibres resulted in different bone formation and biomechanical properties: the 0 /60 /120 scaffolds revealed lower bone formation and biomechanical properties compared to the 0 /90 scaffolds in all the experimental groups. Therefore, future bone regeneration strategies utilizing scaffolds should consider scaffold architecture as an important factor during the scaffold optimization stages in order to move closer to a clinical application. © 2013 International Association of Oral and Maxillofacial Surgeons.|
|Source Title:||International Journal of Oral and Maxillofacial Surgery|
|Appears in Collections:||Staff Publications|
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