Please use this identifier to cite or link to this item: https://doi.org/10.1039/c3tb20680g
Title: Collagen grafted 3D polycaprolactone scaffolds for enhanced cartilage regeneration
Authors: Cai, Y.
Li, J.
Poh, C.K.
Tan, H.C.
San Thian, E. 
Hsi Fuh, J.Y.
Sun, J. 
Tay, B.Y.
Wang, W.
Issue Date: 21-Dec-2013
Citation: Cai, Y., Li, J., Poh, C.K., Tan, H.C., San Thian, E., Hsi Fuh, J.Y., Sun, J., Tay, B.Y., Wang, W. (2013-12-21). Collagen grafted 3D polycaprolactone scaffolds for enhanced cartilage regeneration. Journal of Materials Chemistry B 1 (43) : 5971-5976. ScholarBank@NUS Repository. https://doi.org/10.1039/c3tb20680g
Abstract: Current surgical and repair treatments for articular cartilage defects still do not give satisfactory long-term results. Scaffold-based tissue engineering is the subject of much intensive interest. However, one major hurdle is that it is unable to accurately replicate the internal three dimensional (3D) microstructure of cartilage. In this work, a novel electrohydrodynamic printing (E-Jetting) technique was employed to fabricate 3D polycaprolactone (PCL) scaffolds, followed by collagen grafting mediated by polydopamine. Surface topography, chemical composition, and wettability of the scaffolds before and after surface functionalization were characterized. Porcine chondrocytes were seeded within the scaffolds for chondrogenesis evaluation. The results showed that a 3D PCL scaffold with controlled fibre diameter, orientation, and pore size was fabricated by the E-Jetting system. The surface functionalization made the PCL scaffold hydrophilic and favourable for cell attachment. The chondrocytes maintained their healthy phenotypes within the collagen grafted PCL scaffold. The increased production of sulfated glycosaminoglycan and highly expressed collagen type II demonstrated that collagen had a positive role in stimulating chondrogenesis and the collagen grafted PCL scaffold was effective in cartilage regeneration. © 2013 The Royal Society of Chemistry.
Source Title: Journal of Materials Chemistry B
URI: http://scholarbank.nus.edu.sg/handle/10635/84440
ISSN: 20507518
DOI: 10.1039/c3tb20680g
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

22
checked on Jul 17, 2018

WEB OF SCIENCETM
Citations

19
checked on Jul 17, 2018

Page view(s)

61
checked on Jul 6, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.