Optical virtual imaging at 50 nm lateral resolution with a white-light nanoscope

Abstract

The imaging resolution of a conventional optical microscope is limited by diffraction to ∼200 nm in the visible spectrum. Efforts to overcome such limits have stimulated the development of optical nanoscopes using metamaterial superlenses, nanoscale solid immersion lenses and molecular fluorescence microscopy. These techniques either require an illuminating laser beam to resolve to 70 nm in the visible spectrum or have limited imaging resolution above 100 nm for a white-light source. Here we report a new 50-nm-resolution nanoscope that uses optically transparent microspheres (for example, SiO 2, with 2 μm