Please use this identifier to cite or link to this item:
|Title:||A mathematical model for ATP-mediated calcium dynamics in vascular endothelial cells induced by fluid shear stress|
|Keywords:||ATP (adenosine triphosphate)|
Vascular endothelial cells
|Citation:||Hu, X.-Q., Xiang, C., Cao, L.-L., Xu, Z., Qin, K.-R. (2008-10). A mathematical model for ATP-mediated calcium dynamics in vascular endothelial cells induced by fluid shear stress. Applied Mathematics and Mechanics (English Edition) 29 (10) : 1291-1298. ScholarBank@NUS Repository. https://doi.org/10.1007/s10483-008-1004-4|
|Abstract:||In consideration of the mechanism for shear-stress-induced Ca2+ influx via ATP(adenosine triphosphate)-gated ion channel P2X4 in vascular endothelial cells, a modified model is proposed to describe the shear-stress-induced Ca2+ influx. It is affected both by the Ca 2+ gradient across the cell membrane and extracellular ATP concentration on the cell surface. Meanwhile, a new static ATP release model is constructed by using published experimental data. Combining the modified intracellular calcium dynamics model with the new ATP release model, we establish a nonlinear Ca2+ dynamic system in vascular endothelial cells. The ATP-mediated calcium response in vascular endothelial cells subjected to shear stresses is analyzed by solving the governing equations of the integrated dynamic system. Numerical results show that the shear-stress-induced calcium response predicted by the proposed model is more consistent with the experimental observations than that predicted by existing models. © 2008 Shanghai University and Springer-Verlag GmbH.|
|Source Title:||Applied Mathematics and Mechanics (English Edition)|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 21, 2019
WEB OF SCIENCETM
checked on Mar 12, 2019
checked on Jan 26, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.