Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/79479
Title: Potential Applications of Chitosan-Based Hydrogels in Regenerative Medicine
Authors: RUSDIANTO BUDIRAHARJO
Keywords: chitosan hydrogel, covalent immobilization, mineralization, growth factor, hydroxyapatite, regenerative medicine
Issue Date: 5-Jun-2013
Source: RUSDIANTO BUDIRAHARJO (2013-06-05). Potential Applications of Chitosan-Based Hydrogels in Regenerative Medicine. ScholarBank@NUS Repository.
Abstract: Four potential applications of chitosan-based hydrogels are highlighted in this thesis. In the first study, chitosan films with covalently immobilized bone morphogenetic protein-2 (BMP-2) or fibroblast growth factor-2 (FGF-2) stimulated osteoblast and fibroblast functions to a greater extent than corresponding films with adsorbed BMP-2 or FGF-2. In the second study, BMP-2 and vascular endothelial growth factor (VEGF) were covalently co-immobilized on chitosan films for simultaneous stimulation of osteoblast and endothelial colony forming cells. Hydroxyapatite (HAP)-coated carboxymethyl chitosan (CMCS) scaffolds were evaluated as potential bone graft substitutes in the third study, resulting in better promotion of osteoblast functions and osteogenic differentiation of bone marrow stem cells than non-coated CMCS scaffold. Finally, mineral trioxide aggregate (MTA)-coated CMCS scaffolds were tested as dentin remineralization patches in a tooth model. The scaffolds significantly induced higher HAP mineralization than non-coated CMCS scaffold.
URI: http://scholarbank.nus.edu.sg/handle/10635/79479
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
BudiraharjoR.pdf18.98 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

121
checked on Feb 16, 2018

Download(s)

97
checked on Feb 16, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.