Please use this identifier to cite or link to this item: https://doi.org/10.1016/S1040-8428(01)00216-5
Title: Gold derivatives for the treatment of cancer
Authors: Tiekink, E.R.T. 
Keywords: Cancer
Gold(I)
Gold(III)
Phosphines
Rheumatoid arthritis
Thiolates
Issue Date: 2002
Source: Tiekink, E.R.T. (2002). Gold derivatives for the treatment of cancer. Critical Reviews in Oncology/Hematology 42 (3) : 225-248. ScholarBank@NUS Repository. https://doi.org/10.1016/S1040-8428(01)00216-5
Abstract: The cytotoxicity and anti-tumour activity screening trials for both gold(I) and gold(III) are summarised. Gold(I) thiolates employed clinically in the treatment of rheumatoid arthritis display some potency against various tumours but a greater potential is found in their analogues. In particular, analogues featuring a linear P-Au-S arrangement in which the thiolate ligand is derived from a biologically active thiol display high potency. Further, targeting mitochondria with tetrahedrally coordinated gold(I) phosphine compounds with enhanced hydrophilicity is a research direction with exciting potential. Recent research has shown that gold(III) compounds featuring square-planar geometries, as found in cisplatin, may target DNA and may provide new anti-tumour agents. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Source Title: Critical Reviews in Oncology/Hematology
URI: http://scholarbank.nus.edu.sg/handle/10635/77610
ISSN: 10408428
DOI: 10.1016/S1040-8428(01)00216-5
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