Please use this identifier to cite or link to this item: https://doi.org/10.1016/S1040-8428(01)00216-5
Title: Gold derivatives for the treatment of cancer
Authors: Tiekink, E.R.T. 
Keywords: Cancer
Gold(I)
Gold(III)
Phosphines
Rheumatoid arthritis
Thiolates
Issue Date: 2002
Citation: Tiekink, E.R.T. (2002). Gold derivatives for the treatment of cancer. Critical Reviews in Oncology/Hematology 42 (3) : 225-248. ScholarBank@NUS Repository. https://doi.org/10.1016/S1040-8428(01)00216-5
Abstract: The cytotoxicity and anti-tumour activity screening trials for both gold(I) and gold(III) are summarised. Gold(I) thiolates employed clinically in the treatment of rheumatoid arthritis display some potency against various tumours but a greater potential is found in their analogues. In particular, analogues featuring a linear P-Au-S arrangement in which the thiolate ligand is derived from a biologically active thiol display high potency. Further, targeting mitochondria with tetrahedrally coordinated gold(I) phosphine compounds with enhanced hydrophilicity is a research direction with exciting potential. Recent research has shown that gold(III) compounds featuring square-planar geometries, as found in cisplatin, may target DNA and may provide new anti-tumour agents. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Source Title: Critical Reviews in Oncology/Hematology
URI: http://scholarbank.nus.edu.sg/handle/10635/77610
ISSN: 10408428
DOI: 10.1016/S1040-8428(01)00216-5
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

230
checked on Sep 12, 2018

WEB OF SCIENCETM
Citations

211
checked on Sep 12, 2018

Page view(s)

48
checked on Jul 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.