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Title: Two-Step Liquid-Liquid-Liquid Microextraction of Nonsteroidal Antiinflammatory Drugs in Wastewater
Authors: Wen, X.
Tu, C.
Lee, H.K. 
Issue Date: 1-Jan-2004
Citation: Wen, X., Tu, C., Lee, H.K. (2004-01-01). Two-Step Liquid-Liquid-Liquid Microextraction of Nonsteroidal Antiinflammatory Drugs in Wastewater. Analytical Chemistry 76 (1) : 228-232. ScholarBank@NUS Repository.
Abstract: A simple and novel two-step liquid-liquid-liquid microextraction technique combined with reversed-phase HPLC has been developed for the determination of the nonsteroidal antiinflammatory drugs ibuprofen and 2-(4-chlorophenoxy)-2-methylpropionic acid in wastewater samples. In the first step, the analytes were extracted from an acidified sample (donor solution) into 1-octanol immobilized in the pores of 10 pieces of polypropylene hollow fiber and further into a basic acceptor phase inside the hollow fiber channels. This first extraction step, using 0.01 M NaOH as the acceptor phase and 0.1 M HCl within the donor phase, had a 100% relative recovery with an enrichment factor of 100-fold. The extract in the first step was then adjusted to acidic condition with HCl. It now represented the donor phase for the second step of the extraction, using a single piece of hollow fiber, with 2 μL of 0.01 M NaOH solution as the acceptor phase. This analyte-enriched acceptor phase was subsequently withdrawn into a microsyringe and directly injected into an HPLC system for analysis. With this two-step microextraction, sensitivity enhancement of > 15 000-fold could be obtained. Detection limits of ≤ 100 ng/L could be achieved for both compounds. The method was applied to the analysis of wastewater.
Source Title: Analytical Chemistry
ISSN: 00032700
DOI: 10.1021/ac0302354
Appears in Collections:Staff Publications

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