Please use this identifier to cite or link to this item: https://doi.org/10.1021/co200136b
Title: Synthesis of a novel BODIPY library and its application in the discovery of a fructose sensor
Authors: Zhai, D.
Lee, S.-C.
Vendrell, M.
Leong, L.P. 
Chang, Y.-T. 
Keywords: chemosensor
fluorescence
molecular recognition
saccharides
Issue Date: 13-Feb-2012
Citation: Zhai, D., Lee, S.-C., Vendrell, M., Leong, L.P., Chang, Y.-T. (2012-02-13). Synthesis of a novel BODIPY library and its application in the discovery of a fructose sensor. ACS Combinatorial Science 14 (2) : 81-84. ScholarBank@NUS Repository. https://doi.org/10.1021/co200136b
Abstract: We prepared a new library of 160 compounds by conjugation of a BODIPY core to a collection of aldehydes. This library was screened against 52 biologically relevant analytes and we identified one fluorescent sensor of fructose (Fructose Orange). Fructose Orange showed a 24-fold fluorescence increase upon recognition of fructose and an outstanding selectivity among 24 different saccharides. NMR studies confirmed that five different binding interactions were formed between the sensor and fructose. Furthermore, Fructose Orange was applied to the quantification of fructose in soft drinks, being the most selective fluorescent sensor for fructose reported to date. © 2012 American Chemical Society.
Source Title: ACS Combinatorial Science
URI: http://scholarbank.nus.edu.sg/handle/10635/77174
ISSN: 21568952
DOI: 10.1021/co200136b
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