Please use this identifier to cite or link to this item: https://doi.org/10.1055/s-0032-1317923
Title: Synthesis of 3,4-disubsituted isoxazoles via enamine [3+2] cycloaddition
Authors: Jia, Q.-F.
Benjamin, P.S.
Huang, J.
Du, Z.
Zheng, X.
Zhang, K.
Conney, A.H.
Wang, J. 
Keywords: 1,3-dipoles
[3+2] cycloaddition
enamines
isoxazole
Issue Date: 2013
Citation: Jia, Q.-F., Benjamin, P.S., Huang, J., Du, Z., Zheng, X., Zhang, K., Conney, A.H., Wang, J. (2013). Synthesis of 3,4-disubsituted isoxazoles via enamine [3+2] cycloaddition. Synlett 24 (1) : 79-84. ScholarBank@NUS Repository. https://doi.org/10.1055/s-0032-1317923
Abstract: Enamine-triggered [3+2]-cycloaddition reactions of aldehydes and N-hydroximidoyl chlorides in the presence of triethylamine give rise to 3,4-disubstituted isoxazoles upon oxidation of the cycloadduct 3,4,5-trisubstituted 5-(pyrrolidinyl)-4,5-dihydroisoxazoles. This offers a high yielding, regiospecific and metal-free synthetic route for the synthesis of 3,4-disubstituted isoxazoles. © Georg Thieme Verlag Stuttgart · New York.
Source Title: Synlett
URI: http://scholarbank.nus.edu.sg/handle/10635/77170
ISSN: 09365214
DOI: 10.1055/s-0032-1317923
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