Synthesis of 3,4-disubsituted isoxazoles via enamine [3+2] cycloaddition

Please use this identifier to cite or link to this item: https://doi.org/10.1055/s-0032-1317923

Title:	Synthesis of 3,4-disubsituted isoxazoles via enamine [3+2] cycloaddition
Authors:	Jia, Q.-F. Benjamin, P.S. Huang, J. Du, Z. Zheng, X. Zhang, K. Conney, A.H. Wang, J.
Keywords:	1,3-dipoles [3+2] cycloaddition enamines isoxazole
Issue Date:	2013
Citation:	Jia, Q.-F., Benjamin, P.S., Huang, J., Du, Z., Zheng, X., Zhang, K., Conney, A.H., Wang, J. (2013). Synthesis of 3,4-disubsituted isoxazoles via enamine [3+2] cycloaddition. Synlett 24 (1) : 79-84. ScholarBank@NUS Repository. https://doi.org/10.1055/s-0032-1317923
Abstract:	Enamine-triggered [3+2]-cycloaddition reactions of aldehydes and N-hydroximidoyl chlorides in the presence of triethylamine give rise to 3,4-disubstituted isoxazoles upon oxidation of the cycloadduct 3,4,5-trisubstituted 5-(pyrrolidinyl)-4,5-dihydroisoxazoles. This offers a high yielding, regiospecific and metal-free synthetic route for the synthesis of 3,4-disubstituted isoxazoles. © Georg Thieme Verlag Stuttgart · New York.
Source Title:	Synlett
URI:	http://scholarbank.nus.edu.sg/handle/10635/77170
ISSN:	09365214
DOI:	10.1055/s-0032-1317923
Appears in Collections:	Staff Publications

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