Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol0340888
Title: Solid-phase synthesis of pyrazolines and isoxazolines with sodium benzenesulfinate as a traceless linker
Authors: Chen, Yu.
Lam, Y. 
Lai, Y.-H. 
Issue Date: 3-Apr-2003
Citation: Chen, Yu., Lam, Y., Lai, Y.-H. (2003-04-03). Solid-phase synthesis of pyrazolines and isoxazolines with sodium benzenesulfinate as a traceless linker. Organic Letters 5 (7) : 1067-1069. ScholarBank@NUS Repository. https://doi.org/10.1021/ol0340888
Abstract: (Matrix presented) The preparation of pyrazoline and isoxazoline derivatives with traceless solid-phase sulfone linker strategy is described. Key steps involved in the solid-phase synthetic procedure include (i) sulfinate S-alkylation, (ii) sulfone anion alkylation, (iii) γ-hydroxy sulfone → γ-ketosulfone oxidation, and (iv) traceless product release via elimination-cyclization. A library of 12 pyrazolines and isoxazolines was synthesized.
Source Title: Organic Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/77012
ISSN: 15237060
DOI: 10.1021/ol0340888
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