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|Title:||Solid-Phase Synthesis of Imidazo[1,2-a]pyridine Using Sodium Benzenesulfinate as a Traceless Linker|
|Authors:||Chen, Y. |
|Citation:||Chen, Y., Lam, Y., Lai, Y.-H. (2002-10-31). Solid-Phase Synthesis of Imidazo[1,2-a]pyridine Using Sodium Benzenesulfinate as a Traceless Linker. Organic Letters 4 (22) : 3935-3937. ScholarBank@NUS Repository. https://doi.org/10.1021/ol026797b|
|Abstract:||(equation presented) The preparation of the first library of imidazo[1,2-a]pyridine derivatives on a solid support is described. A sulfone linker strategy was applied in the synthesis. Key steps involved in the solid-phase synthetic procedure include (i) a-haloketone resin formation by sulfinate - sulfone alkylation, (ii) imidazo[1,2-a]pyridine ring formation by treatment with 2-aminopyridine, (iii) sulfone anion alkylation, and (iv) traceless product release by oxidation-elimination. A library of 12 imidazo[1,2-a]pyridines was synthesized.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
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