Please use this identifier to cite or link to this item: https://doi.org/10.1021/cc0500295
Title: Solid-phase synthesis of 3,4-dihydro-1H-pyrimidine-2-ones using sodium benzenesulfinate as a traceless linker
Authors: Li, W.
Lam, Y. 
Issue Date: Sep-2005
Citation: Li, W., Lam, Y. (2005-09). Solid-phase synthesis of 3,4-dihydro-1H-pyrimidine-2-ones using sodium benzenesulfinate as a traceless linker. Journal of Combinatorial Chemistry 7 (5) : 721-725. ScholarBank@NUS Repository. https://doi.org/10.1021/cc0500295
Abstract: The facile preparation of 3,4-dihydropyrimidine-2-one derivatives with traceless solid-phase sulfone linker strategy is described. Key steps involved in the solid-phase synthetic procedure include (i) sulfinate acidification, (ii) condensation of urea or thiourea with aldehydes and sulfinic acid, and (iii) traceless product release via a one-pot cyclization-dehydration process. A library of 18 compounds was synthesized. © 2005 American Chemical Society.
Source Title: Journal of Combinatorial Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/77009
ISSN: 15204766
DOI: 10.1021/cc0500295
Appears in Collections:Staff Publications

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