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|Title:||Solid-phase synthesis of 3,4-dihydro-1H-pyrimidine-2-ones using sodium benzenesulfinate as a traceless linker|
|Citation:||Li, W., Lam, Y. (2005-09). Solid-phase synthesis of 3,4-dihydro-1H-pyrimidine-2-ones using sodium benzenesulfinate as a traceless linker. Journal of Combinatorial Chemistry 7 (5) : 721-725. ScholarBank@NUS Repository. https://doi.org/10.1021/cc0500295|
|Abstract:||The facile preparation of 3,4-dihydropyrimidine-2-one derivatives with traceless solid-phase sulfone linker strategy is described. Key steps involved in the solid-phase synthetic procedure include (i) sulfinate acidification, (ii) condensation of urea or thiourea with aldehydes and sulfinic acid, and (iii) traceless product release via a one-pot cyclization-dehydration process. A library of 18 compounds was synthesized. © 2005 American Chemical Society.|
|Source Title:||Journal of Combinatorial Chemistry|
|Appears in Collections:||Staff Publications|
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