Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/76961
Title: Separation of tamoxifen and metabolites by capillary electrophoresis with non-aqueous buffer system
Authors: Ng, C.L.
Lee, H.K. 
Li, S.F.Y. 
Issue Date: Nov-1994
Source: Ng, C.L.,Lee, H.K.,Li, S.F.Y. (1994-11). Separation of tamoxifen and metabolites by capillary electrophoresis with non-aqueous buffer system. Journal of Liquid Chromatography 17 (18) : 3847-3857. ScholarBank@NUS Repository.
Abstract: Tamoxifen and its metabolites were separated using a non-aqueous mobile phase consisting of ammonium acetate and a mixture of organic solvents, namely, methanol and acetonitrile. The effects of using other organic salts as the conducting medium and varying the composition of the mixture of acetonitrile and methanol on the separation were also investigated. Optimum separation was obtained by using 25 mM ammonium acetate in a 50:50 acetonitrile/methanol mixture. High efficiency separations and short analysis times of less than 8 min were obtained. The reproducibility of migration time was better than 0.4%. The detection limits of tamoxifen and its metabolites were less than 40 pg.
Source Title: Journal of Liquid Chromatography
URI: http://scholarbank.nus.edu.sg/handle/10635/76961
ISSN: 01483919
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

33
checked on Feb 17, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.