Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00216-006-0511-5
Title: Recent developments in microarray-based enzyme assays: From functional annotation to substrate/inhibitor fingerprinting
Authors: Sun, H.
Chattopadhaya, S.
Wang, J.
Yao, S.Q. 
Keywords: Activity-based fingerprinting
Activity-based probe
Catalomics
Drug discovery
Enzyme assay
Inhibitor fingerprinting
Microarray
Issue Date: Oct-2006
Citation: Sun, H., Chattopadhaya, S., Wang, J., Yao, S.Q. (2006-10). Recent developments in microarray-based enzyme assays: From functional annotation to substrate/inhibitor fingerprinting. Analytical and Bioanalytical Chemistry 386 (3) : 416-426. ScholarBank@NUS Repository. https://doi.org/10.1007/s00216-006-0511-5
Abstract: Recent advances in proteomics have provided impetus towards the development of robust technologies for high-throughput studies of enzymes. The term "catalomics" defines an emerging '-omics' field in which high-throughput studies of enzymes are carried out by using advanced chemical proteomics approaches. Of the various available methods, microarrays have emerged as a powerful and versatile platform to accelerate not only the functional annotation but also the substrate and inhibitor specificity (e.g. substrate and inhibitor fingerprinting, respectively) of enzymes. Herein, we review recent developments in the fabrication of various types of microarray technologies (protein-, peptide- and small-molecule-based microarrays) and their applications in high-throughput characterizations of enzymes. © Springer-Verlag 2006.
Source Title: Analytical and Bioanalytical Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/76870
ISSN: 16182642
DOI: 10.1007/s00216-006-0511-5
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