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|Title:||Rapid assembly of matrix metalloprotease inhibitors using click chemistry|
|Citation:||Wang, J., Uttamchandani, M., Li, J., Hu, M., Yao, S.Q. (2006-08-17). Rapid assembly of matrix metalloprotease inhibitors using click chemistry. Organic Letters 8 (17) : 3821-3824. ScholarBank@NUS Repository. https://doi.org/10.1021/ol061431a|
|Abstract:||A panel of 96 metalloprotease inhibitors was assembled using "click chemistry" by reacting eight zinc-binding hydroxamate warheads with 12 azide building blocks. Screens of the bidentate compounds against representative metalloproteases provided discerning inhibition fingerprints, revealing compounds with low micromolar potency against MMP-7. The relative ease and convenience of the strategy in constructing focused chemical libraries for rapid in situ screening of MMPs is thereby demonstrated. © 2006 American Chemical Society.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
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