Please use this identifier to cite or link to this item:
|Title:||Rapid assembly of matrix metalloprotease inhibitors using click chemistry|
|Citation:||Wang, J., Uttamchandani, M., Li, J., Hu, M., Yao, S.Q. (2006-08-17). Rapid assembly of matrix metalloprotease inhibitors using click chemistry. Organic Letters 8 (17) : 3821-3824. ScholarBank@NUS Repository. https://doi.org/10.1021/ol061431a|
|Abstract:||A panel of 96 metalloprotease inhibitors was assembled using "click chemistry" by reacting eight zinc-binding hydroxamate warheads with 12 azide building blocks. Screens of the bidentate compounds against representative metalloproteases provided discerning inhibition fingerprints, revealing compounds with low micromolar potency against MMP-7. The relative ease and convenience of the strategy in constructing focused chemical libraries for rapid in situ screening of MMPs is thereby demonstrated. © 2006 American Chemical Society.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 11, 2018
WEB OF SCIENCETM
checked on Jul 25, 2018
checked on May 11, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.