Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol061431a
Title: Rapid assembly of matrix metalloprotease inhibitors using click chemistry
Authors: Wang, J.
Uttamchandani, M. 
Li, J.
Hu, M.
Yao, S.Q. 
Issue Date: 17-Aug-2006
Source: Wang, J., Uttamchandani, M., Li, J., Hu, M., Yao, S.Q. (2006-08-17). Rapid assembly of matrix metalloprotease inhibitors using click chemistry. Organic Letters 8 (17) : 3821-3824. ScholarBank@NUS Repository. https://doi.org/10.1021/ol061431a
Abstract: A panel of 96 metalloprotease inhibitors was assembled using "click chemistry" by reacting eight zinc-binding hydroxamate warheads with 12 azide building blocks. Screens of the bidentate compounds against representative metalloproteases provided discerning inhibition fingerprints, revealing compounds with low micromolar potency against MMP-7. The relative ease and convenience of the strategy in constructing focused chemical libraries for rapid in situ screening of MMPs is thereby demonstrated. © 2006 American Chemical Society.
Source Title: Organic Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/76853
ISSN: 15237060
DOI: 10.1021/ol061431a
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