Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201307803
Title: Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains
Authors: Zhang, C.-J.
Tan, C.Y.J.
Ge, J.
Na, Z.
Chen, G.Y.J. 
Uttamchandani, M.
Sun, H.
Yao, S.Q. 
Keywords: bioorthogonal chemistry
epigenetics
inhibitors
protein-protein interactions
small-molecule microarrays
Issue Date: 23-Dec-2013
Citation: Zhang, C.-J., Tan, C.Y.J., Ge, J., Na, Z., Chen, G.Y.J., Uttamchandani, M., Sun, H., Yao, S.Q. (2013-12-23). Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains. Angewandte Chemie - International Edition 52 (52) : 14060-14064. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201307803
Abstract: Fast and efficient: A library of trans-cyclooctene (TCO)-modified small molecules were immobilized on tetrazine-functionalized glass slides by using the fastest bioorthogonal reaction known. The resulting small-molecule microarray was screened against a variety of human bromodomains to identify protein-protein interaction inhibitors. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/76812
ISSN: 14337851
DOI: 10.1002/anie.201307803
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