Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains

Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201307803

Title:	Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains
Authors:	Zhang, C.-J. Tan, C.Y.J. Ge, J. Na, Z. Chen, G.Y.J. Uttamchandani, M. Sun, H. Yao, S.Q.
Keywords:	bioorthogonal chemistry epigenetics inhibitors protein-protein interactions small-molecule microarrays
Issue Date:	23-Dec-2013
Citation:	Zhang, C.-J., Tan, C.Y.J., Ge, J., Na, Z., Chen, G.Y.J., Uttamchandani, M., Sun, H., Yao, S.Q. (2013-12-23). Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains. Angewandte Chemie - International Edition 52 (52) : 14060-14064. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201307803
Abstract:	Fast and efficient: A library of trans-cyclooctene (TCO)-modified small molecules were immobilized on tetrazine-functionalized glass slides by using the fastest bioorthogonal reaction known. The resulting small-molecule microarray was screened against a variety of human bromodomains to identify protein-protein interaction inhibitors. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title:	Angewandte Chemie - International Edition
URI:	http://scholarbank.nus.edu.sg/handle/10635/76812
ISSN:	14337851
DOI:	10.1002/anie.201307803
Appears in Collections:	Staff Publications

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