Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201307803
Title: Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains
Authors: Zhang, C.-J.
Tan, C.Y.J.
Ge, J.
Na, Z.
Chen, G.Y.J. 
Uttamchandani, M.
Sun, H.
Yao, S.Q. 
Keywords: bioorthogonal chemistry
epigenetics
inhibitors
protein-protein interactions
small-molecule microarrays
Issue Date: 23-Dec-2013
Source: Zhang, C.-J., Tan, C.Y.J., Ge, J., Na, Z., Chen, G.Y.J., Uttamchandani, M., Sun, H., Yao, S.Q. (2013-12-23). Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains. Angewandte Chemie - International Edition 52 (52) : 14060-14064. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201307803
Abstract: Fast and efficient: A library of trans-cyclooctene (TCO)-modified small molecules were immobilized on tetrazine-functionalized glass slides by using the fastest bioorthogonal reaction known. The resulting small-molecule microarray was screened against a variety of human bromodomains to identify protein-protein interaction inhibitors. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/76812
ISSN: 14337851
DOI: 10.1002/anie.201307803
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

23
checked on Feb 22, 2018

WEB OF SCIENCETM
Citations

24
checked on Jan 22, 2018

Page view(s)

63
checked on Feb 19, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.