Please use this identifier to cite or link to this item:
|Title:||Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease|
|Source:||Im, J., Kim, S., Jeong, Y.-H., Kim, W., Lee, D., Lee, W.S., Chang, Y.-T., Kim, K.-T., Chung, S.-K. (2013-02). Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease. MedChemComm 4 (2) : 310-316. ScholarBank@NUS Repository. https://doi.org/10.1039/c2md20112g|
|Abstract:||The BBB-permeable trehalose derivative (TD-G6) was found to efficiently prevent the aggregation of polyQ in the transfected HEK293 cells. Furthermore, it was also found to significantly prolong lifespan, improve motor functions, and reduce the inclusion bodies in a transgenic mouse model (Tg R6/2), when given ad libitum. This journal is © The Royal Society of Chemistry.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 22, 2018
WEB OF SCIENCETM
checked on Jan 22, 2018
checked on Feb 19, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.