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|Title:||Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease|
|Citation:||Im, J., Kim, S., Jeong, Y.-H., Kim, W., Lee, D., Lee, W.S., Chang, Y.-T., Kim, K.-T., Chung, S.-K. (2013-02). Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease. MedChemComm 4 (2) : 310-316. ScholarBank@NUS Repository. https://doi.org/10.1039/c2md20112g|
|Abstract:||The BBB-permeable trehalose derivative (TD-G6) was found to efficiently prevent the aggregation of polyQ in the transfected HEK293 cells. Furthermore, it was also found to significantly prolong lifespan, improve motor functions, and reduce the inclusion bodies in a transgenic mouse model (Tg R6/2), when given ad libitum. This journal is © The Royal Society of Chemistry.|
|Appears in Collections:||Staff Publications|
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