Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2md20112g
Title: Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease
Authors: Im, J.
Kim, S.
Jeong, Y.-H.
Kim, W.
Lee, D.
Lee, W.S.
Chang, Y.-T. 
Kim, K.-T.
Chung, S.-K.
Issue Date: Feb-2013
Citation: Im, J., Kim, S., Jeong, Y.-H., Kim, W., Lee, D., Lee, W.S., Chang, Y.-T., Kim, K.-T., Chung, S.-K. (2013-02). Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease. MedChemComm 4 (2) : 310-316. ScholarBank@NUS Repository. https://doi.org/10.1039/c2md20112g
Abstract: The BBB-permeable trehalose derivative (TD-G6) was found to efficiently prevent the aggregation of polyQ in the transfected HEK293 cells. Furthermore, it was also found to significantly prolong lifespan, improve motor functions, and reduce the inclusion bodies in a transgenic mouse model (Tg R6/2), when given ad libitum. This journal is © The Royal Society of Chemistry.
Source Title: MedChemComm
URI: http://scholarbank.nus.edu.sg/handle/10635/76809
ISSN: 20402503
DOI: 10.1039/c2md20112g
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